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Nonafluorobutanesulfonic anhydride (CAS 36913-91-4)

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Alternate Names:
Perfluorobutane-1-sulphonic anhydride
CAS Number:
36913-91-4
Molecular Weight:
582.18
Molecular Formula:
C8F18O5S2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Nonafluorobutanesulphonic anhydride, also known as NFBSA, is a fluorinated organic compound with a wide range of applications in scientific research. Its significance lies in being an anhydride of nonafluorobutane-1-sulphonic acid and serving as a intermediate in the synthesis of various fluorinated materials. Thanks to its exceptional properties, Nonafluorobutanesulfonic anhydride finds utility as a surfactant, a catalyst, and a cross-linking agent in diverse fields. As a surfactant, Nonafluorobutanesulfonic anhydride enhances the solubility of hydrophobic substances, while acting as a catalyst in a variety of organic reactions. Additionally, it plays a vital role as a cross-linking agent, contributing to the formation of polymers. Moreover, this compound is instrumental in functionalizing surfaces and altering material properties to suit specific needs. The mechanism of action of Nonafluorobutanesulphonic anhydride remains somewhat elusive, but it is hypothesized to involve the creation of a highly reactive intermediate species. This species forms when the anhydride group of NFBSA reacts with nucleophiles like alcohols, resulting in the formation of new chemical bonds. Subsequently, this intermediate species exhibits the capability to interact with various substrates, including hydrophobic compounds, thereby generating novel products. Nonafluorobutanesulfonic anhydride′s versatility and unique properties have led to its widespread application in scientific research, making it an invaluable component in the development of innovative fluorinated materials.


Nonafluorobutanesulfonic anhydride (CAS 36913-91-4) References

  1. Synthesis of ladder-type pi-conjugated heteroacenes via palladium-catalyzed double N-arylation and intramolecular O-arylation.  |  Kawaguchi, K., et al. 2007. J Org Chem. 72: 5119-28. PMID: 17552565
  2. Synthesis of the positron-emitting radiotracer [(18)F]-2-fluoro-2-deoxy-D-glucose from resin-bound perfluoroalkylsulfonates.  |  Brown, LJ., et al. 2009. Org Biomol Chem. 7: 564-75. PMID: 19156324
  3. Synthesis of 4-Arylthieno[2,3-b]pyridines and 4-Aminothieno[2,3-b]pyridines via a Regioselective Bromination of Thieno[2,3-b]pyridine.  |  Lucas, SC., et al. 2015. J Org Chem. 80: 12594-8. PMID: 26584084
  4. Zur Alkylierung von 1,3-Dithietan-1,1,3,3-tetroxid (Disulfen) mit Nonafluorbutansulfonsäureestern  |  Markus Frasch, Wolfgang Sundermeyer, Joachim Waldi. 1991. Chemische Berichte. 124: 1805-1807.
  5. Highly soluble fluorous alkyl ether-tagged imaging materials for the photo-patterning of organic light-emitting devices  |  Jongchan Son,a Hyun-Taek Oh,a O Jun Kwon,b Jong-Min Lim,c Heeyoung Jung,d Byung Jun Jung,b Do-Hoon Hwang,c Changhee Lee,d Jin-Kyun Lee, *a Jong Geun Yoone and Soo Young Yoone . 2017. J. Mater. Chem. C,. 5: 926-930.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Nonafluorobutanesulfonic anhydride, 1 g

sc-236188
1 g
$40.00

Nonafluorobutanesulfonic anhydride, 5 g

sc-236188A
5 g
$110.00