Molecular structure of Nicergoline, CAS Number: 27848-84-6
Nicergoline (CAS 27848-84-6)
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Alternate Names:
5-Bromonicotinic acid 10-methoxy-1,6-dimethylergoline-8-methyl ester
Application:
Nicergoline is an α-adrenergic modulator and vasodilator
CAS Number:
27848-84-6
Purity:
≥98%
Molecular Weight:
484.39
Molecular Formula:
C24H26BrN3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Nicergoline, also referred to as Nivalin, Sermion, Nicergolin, or nicergoline, is a synthetic derivative of ergoline, an alkaloid naturally found in the ergot fungus. Although the precise mechanism of action of nicergoline remains partially unknown, it is believed to involve the activation of multiple receptors, notably the serotonin 5-HT1A and 5-HT1B receptors, along with the dopamine D2 receptor.
Nicergoline (CAS 27848-84-6) References
- Neuroprotective effects of nicergoline in immortalized neurons. | Sortino, MA., et al. 1999. Eur J Pharmacol. 368: 285-90. PMID: 10193666
- Nicergoline facilitates vestibular compensation in aged male rats with unilateral labyrinthectomy. | Rampello, L. and Drago, F. 1999. Neurosci Lett. 267: 93-6. PMID: 10400220
- Nicergoline stimulates protein kinase C mediated alpha-secretase processing of the amyloid precursor protein in cultured human neuroblastoma SH-SY5Y cells. | Cedazo-Minguez, A., et al. 1999. Neurochem Int. 35: 307-15. PMID: 10482351
- Nicergoline enhances glutamate uptake via glutamate transporters in rat cortical synaptosomes. | Nishida, A., et al. 2004. Biol Pharm Bull. 27: 817-20. PMID: 15187425
- Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against beta-amyloid toxicity. | Caraci, F., et al. 2005. Brain Res. 1047: 30-7. PMID: 15882840
- Effects of nicergoline on corneal epithelial wound healing in rat eyes. | Kim, SY., et al. 2009. Invest Ophthalmol Vis Sci. 50: 621-5. PMID: 18836171
- Nicergoline inhibits T-type Ca2+ channels in rat isolated hippocampal CA1 pyramidal neurones. | Takahashi, K. and Akaike, N. 1990. Br J Pharmacol. 100: 705-10. PMID: 2169937
- A systematic review and meta-analysis assessing adverse event profile and tolerability of nicergoline. | Fioravanti, M., et al. 2014. BMJ Open. 4: e005090. PMID: 25079927
- Safety of nicergoline as an agent for management of cognitive function disorders. | Saletu, B., et al. 2014. Biomed Res Int. 2014: 610103. PMID: 25243157
- Nicergoline inhibits human platelet Ca(2+) signalling through triggering a microtubule-dependent reorganization of the platelet ultrastructure. | Walford, T., et al. 2016. Br J Pharmacol. 173: 234-47. PMID: 26450366
- Ameliorative effect of nicergoline on cognitive function through the PI3K/AKT signaling pathway in mouse models of Alzheimer's disease. | Zang, G., et al. 2018. Mol Med Rep. 17: 7293-7300. PMID: 29568940
- Role of nicergoline in corneal wound healing in diabetic rats. | Portela, ALBM., et al. 2021. BMC Ophthalmol. 21: 77. PMID: 33563243
- Effects of nicergoline on the cardiovascular system of dogs and rats. | Huchet, AM., et al. 1981. J Cardiovasc Pharmacol. 3: 677-91. PMID: 6167799
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicergoline, 100 mg | sc-203643 | 100 mg | $91.00 |