netrin-5 Antibody (G-12): sc-514786

netrin-5 Antibody (G-12) is a mouse monoclonal IgM antibody that detects netrin-5 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-netrin-5 antibody (G-12) is available as a non-conjugated format. Netrin-5, also known as NTN5 or netrin-1-like protein, plays a crucial role in the nervous system by providing guidance cues for axonal growth and cell migration during development, which is essential for proper neural network formation. Netrin-5 is secreted and consists of 489 amino acids, existing in two alternatively spliced isoforms. Netrin-5 structure includes three laminin EGF-like domains and one NTR domain, which are vital for interaction with receptors on target cells, facilitating the directional growth of axons. Netrin-5 is encoded by a gene located on human chromosome 19q13.42, a region known for its high gene density and housing numerous immunoglobulin superfamily members. Netrin-5 signaling pathway is influenced by extracellular calcium levels and protein kinase A (PKA) activity, where a decrease in PKA activity can alter axonal responsiveness to netrin proteins, leading to repulsion instead of attraction. This intricate balance of signaling is critical for the correct wiring of the nervous system, highlighting netrin-5′s importance in developmental biology and potential implications in neurodevelopmental disorders.

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netrin-5 Antibody (G-12) References:

1. Netrins and netrin receptors.  |  Livesey, FJ. 1999. Cell Mol Life Sci. 56: 62-8. PMID: 11213262
2. The genomic context of natural killer receptor extended gene families.  |  Trowsdale, J., et al. 2001. Immunol Rev. 181: 20-38. PMID: 11513141
3. Netrins and neogenin promote myotube formation.  |  Kang, JS., et al. 2004. J Cell Biol. 167: 493-504. PMID: 15520228
4. Comparative human-mouse-rat sequence analysis of the ICAM gene cluster on HSA 19p13.2 and a 185-kb porcine region from SSC 2q.  |  Leeb, T. and Müller, M. 2004. Gene. 343: 239-44. PMID: 15588578
5. Axon guidance by diffusible chemoattractants: a gradient of netrin protein in the developing spinal cord.  |  Kennedy, TE., et al. 2006. J Neurosci. 26: 8866-74. PMID: 16928876
6. The extended human leukocyte receptor complex: diverse ways of modulating immune responses.  |  Barrow, AD. and Trowsdale, J. 2008. Immunol Rev. 224: 98-123. PMID: 18759923
7. Lesions and tuberculin sensitivity in calves inoculated with group III mycobacterial isolates from swine, pen soil, and cattle feed.  |  McGavin, MD., et al. 1975. Am J Vet Res. 36: 641-4. PMID: 806238

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-netrin-5 Antibody (G-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-netrin-5 Antibody (G-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

netrin-5 Antibody (G-12) Specifications

Alternate Product Name: netrin-5

Product Clone Name: G-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 252-278

Epitope Target: netrin-5

Epitope Species: human

Product Reactivity/Detection: netrin-5

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for netrin-5 Antibody (G-12): P: Blocking Peptide