NARF Antibody (32-7): sc-100654
- NARF Antibody (32-7) is a mouse monoclonal IgM NARF antibody provided at 200 µl ascites
- raised against recombinant NARF of human origin
- recommended for detection of NARF of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NARF Antibody (32-7). This work is in progress.
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NARF Antibody (32-7) is a mouse monoclonal IgM antibody that detects NARF protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-NARF antibody (32-7) is available as the non-conjugated format. NARF, or nuclear prelamin A recognition factor, is a crucial 456 amino acid nuclear protein that plays a significant role in cellular processes, particularly in prelamin A metabolism. NARF protein is predominantly expressed in the heart, skeletal muscle, and brain, where NARF binds to the C-terminal end of prenylated prelamin A, suggesting involvement in the assembly of a prelamin A-containing endoprotease complex. NARF interaction with prelamin A is vital for maintaining proper heterochromatin organization, which is essential for gene regulation and chromosomal stability. Additionally, NARF undergoes post-translational modifications, including phosphorylation by ATM or ATR in response to DNA damage, highlighting a role in cellular stress responses. Three isoforms of NARF, resulting from alternative splicing, further underscore the complexity and regulatory potential in various biological contexts.
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NARF Antibody (32-7) References:
- Prenylated prelamin A interacts with Narf, a novel nuclear protein. | Barton, RM. and Worman, HJ. 1999. J Biol Chem. 274: 30008-18. PMID: 10514485
- Eukaryotic Fe-hydrogenases -- old eukaryotic heritage or adaptive acquisitions? | Hackstein, JH. 2005. Biochem Soc Trans. 33: 47-50. PMID: 15667261
- NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF). | Yamada, M., et al. 2006. J Biol Chem. 281: 20749-20760. PMID: 16714285
- RNA-editing-mediated exon evolution. | Lev-Maor, G., et al. 2007. Genome Biol. 8: R29. PMID: 17326827
- Pre-Lamin A processing is linked to heterochromatin organization. | Lattanzi, G., et al. 2007. J Cell Biochem. 102: 1149-59. PMID: 17654502
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NARF Antibody (32-7) | sc-100654 | 200 µl ascites | $339.00 |