Molecular structure of N7-(2-Carbamoyl-2-hydroxyethyl)guanine, CAS Number: 163734-06-3
N7-(2-Carbamoyl-2-hydroxyethyl)guanine (CAS 163734-06-3)
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Alternate Names:
N7-GA-Gua; 2-Amino-1,6-dihydro-α-hydroxy-6-oxo-7H-purine-7-propanamide
Application:
N7-(2-Carbamoyl-2-hydroxyethyl)guanine is a DNA adduct of glycidamide
CAS Number:
163734-06-3
Molecular Weight:
238.30
Molecular Formula:
C8H10N6O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N7-(2-Carbamoyl-2-hydroxyethyl)guanine exerts its effect by specifically binding to enzymes responsible for DNA and RNA synthesis, as well as protein synthesis, leading to their inhibition. This binding occurs at the active site of these enzymes, effectively impeding their catalytic activity in carrying out their respective reactions. Additionally, N7-(2-Carbamoyl-2-hydroxyethyl)guanine also binds to the active site of enzymes involved in transcription and translation, effectively hindering their ability to perform their respective functions.
N7-(2-Carbamoyl-2-hydroxyethyl)guanine (CAS 163734-06-3) References
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- Genotoxicity of acrylamide and glycidamide in human lymphoblastoid TK6 cells. | Koyama, N., et al. 2006. Mutat Res. 603: 151-8. PMID: 16387526
- Cytogenetic damage induced by acrylamide and glycidamide in mammalian cells: correlation with specific glycidamide-DNA adducts. | Martins, C., et al. 2007. Toxicol Sci. 95: 383-90. PMID: 17088317
- DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide. | Von Tungeln, LS., et al. 2009. Int J Cancer. 124: 2006-15. PMID: 19123476
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- Toxicokinetics of acrylamide in primary rat hepatocytes: coupling to glutathione is faster than conversion to glycidamide. | Watzek, N., et al. 2013. Arch Toxicol. 87: 1545-56. PMID: 23568512
- Biomarker analysis of hemoglobin adducts of acrylamide and glycidamide enantiomers for mid-term internal exposure assessment by isotope dilution ultra-high performance liquid chromatography tandem mass spectrometry. | Zhang, Y., et al. 2018. Talanta. 178: 825-833. PMID: 29136901
- Feasibility of using urinary N7-(2-carbamoyl-2-hydroxyethyl) Guanine as a biomarker for acrylamide exposed workers. | Huang, YF., et al. 2018. J Expo Sci Environ Epidemiol. 28: 589-598. PMID: 29463903
- Changes of metabolites of acrylamide and glycidamide in acrylamide-exposed rats pretreated with blueberry anthocyanins extract. | Wang, P., et al. 2019. Food Chem. 274: 611-619. PMID: 30372986
- Interaction of Acrylamide, Acrolein, and 5-Hydroxymethylfurfural with Amino Acids and DNA. | Ou, J., et al. 2020. J Agric Food Chem. 68: 5039-5048. PMID: 32275416
- Analysis of N7-(2-carbamoyl-2-hydroxyethyl)guanine in dried blood spot after food exposure by Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry. | Harahap, Y., et al. 2022. BMC Chem. 16: 83. PMID: 36324163
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N7-(2-Carbamoyl-2-hydroxyethyl)guanine, 5 mg | sc-212352 | 5 mg | $393.00 |