Molecular structure of N6-Cyclohexyladenosine, CAS Number: 36396-99-3
N6-Cyclohexyladenosine (CAS 36396-99-3)
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Alternate Names:
CHA
Application:
N6-Cyclohexyladenosine is a selective A1 adenosine receptor agonist
CAS Number:
36396-99-3
Purity:
≥98%
Molecular Weight:
349.38
Molecular Formula:
C16H23N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N6-Cyclohexyladenosine, a synthetic purine nucleoside analog, acts as a selective A1 adenosine receptor agonist, a critical player in diverse biochemical processes. Its mechanism of action primarily involves modulating the A1 adenosine receptor activity, which influences various cellular functions such as signaling pathways, cellular metabolism, and neurotransmission. Research utilizing N6-Cyclohexyladenosine spans a broad spectrum, encompassing investigations into its effects on cellular processes including but not limited to cell proliferation, apoptosis, and gene expression patterns. By selectively activating the A1 adenosine receptor, it provides useful for dissecting the intricate mechanisms through which adenosine influences cell behavior, offering insights into the underlying principles of cellular regulation and signaling networks.
N,[object Object],-Cyclohexyladenosine (CAS 36396-99-3) References
- N6-cyclohexyladenosine and 3-(2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid enhance the effect of antiepileptic drugs against induced seizures in mice. | Assi, AA. 2001. J Pharm Pharm Sci. 4: 42-51. PMID: 11302789
- Anticonvulsant effect of bilateral injection of N6-cyclohexyladenosine into the CA1 region of the hippocampus in amygdala-kindled rats. | Alasvand Zarasvand, M., et al. 2001. Epilepsy Res. 47: 141-9. PMID: 11673028
- Modulation of conventional outflow facility by the adenosine A1 agonist N6-cyclohexyladenosine. | Crosson, CE., et al. 2005. Invest Ophthalmol Vis Sci. 46: 3795-9. PMID: 16186365
- Anticonvulsant effects of N6-cyclohexyladenosine microinjected into the CA1 region of the hippocampus on entorhinal cortex-kindled seizures in rats. | Heidarianpour, A., et al. 2006. Epileptic Disord. 8: 259-66. PMID: 17150438
- The interaction of intrathecal neostigmine and N-cyclohexyladenosine on anti-allodynic effects in rats with a nerve ligation injury. | Choi, DK., et al. 2010. Korean J Anesthesiol. 59: 39-44. PMID: 20651997
- Adenosine A1 receptor agonist, N6-cyclohexyladenosine, protects myelin and induces remyelination in an experimental model of rat optic chiasm demyelination; electrophysiological and histopathological studies. | Asghari, AA., et al. 2013. J Neurol Sci. 325: 22-8. PMID: 23260322
- Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia. | Futatsuki, T., et al. 2018. Sci Rep. 8: 2717. PMID: 29426934
- Precise Control of Target Temperature Using N6-Cyclohexyladenosine and Real-Time Control of Surface Temperature. | Laughlin, BW., et al. 2018. Ther Hypothermia Temp Manag. 8: 108-116. PMID: 29480748
- N6-cyclohexyladenosine inhibits veratridine-stimulated 22Na uptake by rat brain synaptosomes. | Simões, AP., et al. 1988. J Neurochem. 50: 899-903. PMID: 3339363
- Further characterization of the renovascular effects of N6-cyclohexyladenosine in the isolated perfused rat kidney. | Rossi, NF., et al. 1987. J Pharmacol Exp Ther. 240: 911-5. PMID: 3559983
- Adenosine A1 receptor agonist, N6-cyclohexyladenosine, attenuates Huntington's disease via stimulation of TrKB/PI3K/Akt/CREB/BDNF pathway in 3-nitropropionic acid rat model. | Rabie, MA., et al. 2023. Chem Biol Interact. 369: 110288. PMID: 36509115
- An Assessment of Physical and N6-Cyclohexyladenosine-Induced Hypothermia in Rodent Distal Focal Ischemic Stroke. | Liddle, LJ., et al. 2023. Ther Hypothermia Temp Manag.. PMID: 37339459
- Inhibition of the transport of adenosine, other nucleosides and hypoxanthine in novikoff rat hepatoma cells by methylxanthines, papaverine, N6-cyclohexyladenosine and N6-phenylisopropyladenosine. | Plagemann, PG. and Wohlhueter, RM. 1984. Biochem Pharmacol. 33: 1783-8. PMID: 6203540
- The effect of N6-cyclohexyladenosine and 5'-N-ethylcarboxamidoadenosine on body temperature in normothermic rabbits. | Matuszek, M. and Gagało, IT. 1996. Gen Pharmacol. 27: 467-9. PMID: 8723528
- Lack of adenosine causes myocardial refractoriness. | Vogt, AM., et al. 1998. J Am Coll Cardiol. 31: 1134-41. PMID: 9562019
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N6-Cyclohexyladenosine, 50 mg | sc-255385 | 50 mg | $105.00 | |||
N6-Cyclohexyladenosine, 250 mg | sc-255385A | 250 mg | $396.00 |