Molecular structure of N-Trifluoroacetyl Deacetylcolchiceine
N-Trifluoroacetyl Deacetylcolchiceine
Molecular Weight:
439.38
Molecular Formula:
C21H20F3NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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An antimitotic agent that interrupts microtubles by binding to tubulin and preventing polymerization. Stimulates the intrinsic GTPase activity of tubulin. Apoptosis inducer in normal and tumor cell lines and activates the JNK/SAPK signaling.
N-Trifluoroacetyl Deacetylcolchiceine References
- Tubulin structure and biochemistry. | Ludueña, RF., et al. 1992. Curr Opin Cell Biol. 4: 53-7. PMID: 1558754
- Apoptosis in rat hippocampal dentate gyrus after intraventricular colchicine. | Ceccatelli, S., et al. 1997. Neuroreport. 8: 3779-83. PMID: 9427370
- Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. | Wang, TH., et al. 1998. J Biol Chem. 273: 4928-36. PMID: 9478937
- Role of the colchicine ring A and its methoxy groups in the binding to tubulin and microtubule inhibition. | Andreu, JM., et al. 1998. Biochemistry. 37: 8356-68. PMID: 9622487
- Simple conversion of colchicine into demecolcine | Capraro, H. G., & Brossi, A. 1979. Helvetica Chimica Acta. 62(4): 965-970.
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Trifluoroacetyl Deacetylcolchiceine, 100 mg | sc-219250 | 100 mg | $380.00 |