Date published: 2026-5-24

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N-tert-Butylhydroxylamine hydrochloride (CAS 57497-39-9)

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CAS Number:
57497-39-9
Purity:
≥98%
Molecular Weight:
125.60
Molecular Formula:
C4H12ClNO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N-tert-Butylhydroxylamine hydrochloride is a white crystalline substance that dissolves in both water and alcohol. This stable, non-volatile organic compound is often employed in chemical synthesis. As a trimethyl variant of hydroxylamine, it effectively neutralizes nitrous acid, especially when nitrous acid forms from exposure to light and hydrochloric acid. The compound is versatile in synthesis, aiding in the production of azides, isocyanates, and various critical chemical intermediates. Moreover, it finds applications in molecular biology, specifically in the synthesis of peptides and proteins.


N-tert-Butylhydroxylamine hydrochloride (CAS 57497-39-9) References

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  2. Methylenecyclopropane Rearrangement as a Probe for Free Radical Substituent Effects. sigma (*) Values for Potent Radical-Stabilizing Nitrogen-Containing Substituents.  |  Creary, X., et al. 1999. J Org Chem. 64: 5634-5643. PMID: 11674633
  3. Stilbazulenyl nitrone (STAZN): a nitronyl-substituted hydrocarbon with the potency of classical phenolic chain-breaking antioxidants.  |  Becker, DA., et al. 2002. J Am Chem Soc. 124: 4678-84. PMID: 11971716
  4. A novel route to substituted 4-methylene-4,5-dihydroisoxazoles mediated by hafnium(IV) chloride.  |  Dunn, PJ., et al. 2001. Chem Commun (Camb). 1968-9. PMID: 12240243
  5. ESR study of spin-trapping with two glycosylated analogues of PBN able to target cell membrane lectins.  |  Chalier, F., et al. 2004. Org Biomol Chem. 2: 927-34. PMID: 15007424
  6. Spin trapping by use of N-tert-butylhydroxylamine. Involvement of Fenton reactions.  |  Lagercrantz, C. 1991. Free Radic Res Commun. 14: 395-407. PMID: 1663907
  7. Synthesis of alpha-ketoamides by a molecular-sieves-promoted formal oxidative coupling of aliphatic aldehydes with isocyanides.  |  Grassot, JM., et al. 2008. Angew Chem Int Ed Engl. 47: 947-50. PMID: 18092314
  8. Synthesis, structure, theoretical and experimental in vitro antioxidant/pharmacological properties of α-aryl, N-alkyl nitrones, as potential agents for the treatment of cerebral ischemia.  |  Samadi, A., et al. 2011. Bioorg Med Chem. 19: 951-60. PMID: 21190861
  9. Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents.  |  Oliveira, C., et al. 2019. Eur J Med Chem. 174: 116-129. PMID: 31029943
  10. Polyurethane End-Capped by Tetramethylpyrazine-Nitrone for Promoting Endothelialization Under Oxidative Stress.  |  Qu, B., et al. 2019. Adv Healthc Mater. 8: e1900582. PMID: 31529779
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  12. Synthesis and Antioxidant Properties of HeteroBisNitrones Derived from Benzene Dicarbaldehydes.  |  Diez-Iriepa, D., et al. 2022. Antioxidants (Basel). 11: PMID: 36009295
  13. Polyfunctionalized α-Phenyl-tert-butyl(benzyl)nitrones: Multifunctional Antioxidants for Stroke Treatment.  |  Diez-Iriepa, D., et al. 2022. Antioxidants (Basel). 11: PMID: 36139811
  14. Improving the Efficacy of Quinolylnitrones for Ischemic Stroke Therapy, QN4 and QN15 as New Neuroprotective Agents after Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Injury.  |  Alonso, JM., et al. 2022. Pharmaceuticals (Basel). 15: PMID: 36355534
  15. Diboron reagents in the deoxygenation of nitrones.  |  Vargas, EL., et al. 2023. Org Biomol Chem. 21: 807-816. PMID: 36599009

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-tert-Butylhydroxylamine hydrochloride, 1 g

sc-250492
1 g
$64.00