Date published: 2025-9-17

1-800-457-3801

SCBT Portrait Logo
Seach Input

N-Succinyl-5-aminoimidazole-4-carboxamide Ribose 5′-Phosphate (CAS 3031-95-6)

0.0(0)
Write a reviewAsk a question

Alternate Names:
Saicar
CAS Number:
3031-95-6
Molecular Weight:
454.28
Molecular Formula:
C13H19N4O12P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

N-Succinyl-5-aminoimidazole-4-carboxamide Ribose 5′-Phosphate (SAICAR) plays a pivotal role in the purine nucleotide cycle, acting as an intermediate in the biosynthesis of purine ribonucleotides. Its significance extends beyond mere participation in a biochemical pathway; N-Succinyl-5-aminoimidazole-4-carboxamide Ribose 5′-Phosphate is integral in the regulation and catalysis of enzymatic reactions that are for the synthesis of purine nucleotides, which are essential building blocks for DNA and RNA in cellular processes. Moreover, N-Succinyl-5-aminoimidazole-4-carboxamide Ribose 5′-Phosphate has garnered attention in research focusing on cellular metabolism and energy regulation, serving as a tool to elucidate the complex mechanisms governing nucleotide synthesis and turnover. The study of N-Succinyl-5-aminoimidazole-4-carboxamide Ribose 5′-Phosphate and its interactions offers insights into the intricate network of metabolic pathways, providing a deeper understanding of cellular function and the molecular basis of biological processes. Its role in fundamental biochemical pathways makes it a subject of interest in the exploration of the molecular mechanisms underpinning cellular metabolism and genetic information processing.


N-Succinyl-5-aminoimidazole-4-carboxamide Ribose 5′-Phosphate (CAS 3031-95-6) References

  1. SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions.  |  Keller, KE., et al. 2012. Science. 338: 1069-72. PMID: 23086999
  2. Structure of SAICAR synthetase from Pyrococcus horikoshii OT3: insights into thermal stability.  |  Manjunath, K., et al. 2013. Int J Biol Macromol. 53: 7-19. PMID: 23137517
  3. SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells.  |  Keller, KE., et al. 2014. Mol Cell. 53: 700-9. PMID: 24606918
  4. SAICAR binding activates PKM2 protein kinase activity.  |  . 2014. Cancer Discov. 4: OF20. PMID: 24795025
  5. Structural insight into mechanisms for dynamic regulation of PKM2.  |  Wang, P., et al. 2015. Protein Cell. 6: 275-287. PMID: 25645022
  6. Succinyl-5-aminoimidazole-4-carboxamide-1-ribose 5'-Phosphate (SAICAR) Activates Pyruvate Kinase Isoform M2 (PKM2) in Its Dimeric Form.  |  Yan, M., et al. 2016. Biochemistry. 55: 4731-6. PMID: 27481063
  7. The CRISPR-Cas9 crADSL HeLa transcriptome: A first step in establishing a model for ADSL deficiency and SAICAR accumulation.  |  Mazzarino, RC., et al. 2019. Mol Genet Metab Rep. 21: 100512. PMID: 31516833
  8. Multiple functions of pyruvate kinase M2 in various cell types.  |  Lee, YB., et al. 2022. J Cell Physiol. 237: 128-148. PMID: 34311499
  9. A review on the emerging roles of pyruvate kinase M2 in anti-leukemia therapy.  |  Yang, GJ., et al. 2021. Int J Biol Macromol. 193: 1499-1506. PMID: 34740687
  10. Detection of Nail Oncometabolite SAICAR in Oral Cancer Patients and Its Molecular Interactions with PKM2 Enzyme.  |  Patel, R., et al. 2021. Int J Environ Res Public Health. 18: PMID: 34769743
  11. Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.  |  Charoensutthivarakul, S., et al. 2022. ACS Infect Dis. 8: 296-309. PMID: 35037462
  12. Pathway-specific effects of ADSL deficiency on neurodevelopment.  |  Dutto, I., et al. 2022. Elife. 11: PMID: 35133277
  13. Two complementary radiometric methods for the measurement of 5-amino-4-imidazole-N-succinocarboxamide ribonucleotide synthetase (SAICAR synthetase).  |  Tyagi, AK., et al. 1980. J Biochem Biophys Methods. 2: 123-32. PMID: 6999069

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-Succinyl-5-aminoimidazole-4-carboxamide Ribose 5′-Phosphate, 500 µg

sc-474583
500 µg
$439.00