n-Octyl-β-D-glucopyranoside CAS: 29836-26-8
MF: C14H28O6
MW: 292.34

n-Octyl-β-D-glucopyranoside (CAS 29836-26-8)

n-Octyl-β-D-glucopyranoside | CAS 29836-26-8 is rated 4.5 out of 5 by 2.
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Alternate Names: n-Octyl-β-D-glucopyranoside is also known as n-Octylglucoside.
Application: n-Octyl-β-D-glucopyranoside is a mild, non-denaturing nonionic detergent that is used for the solubilization and reconstitution of membrane-bound protein
CAS Number: 29836-26-8
Purity: ≥98%
Molecular Weight: 292.34
Molecular Formula: C14H28O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

n-Octyl-β-D-glucopyranoside is a non–ionic detergent intended for solubilizing membrane–bound proteins in their native state and for the preparation of lipid vesicles. n-Octyl-β-D-glucopyranoside has a well–defined chemical structure, small uniform micelles, and high water solubility, which make n-Octyl-β-D-glucopyranoside superior to most other nonionic detergents for membrane solubilization. Because of the high critical micelle concentration (20-25 mM), n-Octyl-β-D-glucopyranoside has the additional advantage of being removed easily by dialysis when compared to bile salts. n-Octyl-β-D-glucopyranoside is also known as N-Octyl glucoside, OGP, OG, n-Octylglucoside, and octyl-β-D-glucopyranoside.


References

1. Lévy, D., et al., 1992. Reconstitution of the sarcoplasmic reticulum Ca(2+)-ATPase: mechanisms of membrane protein insertion into liposomes during reconstitution procedures involving the use of detergents. Biochimica et biophysica acta. 1107(2): 283-98. PMID: 1387003

2. Hoshino, T., et al., 1992. Solubilization and reconstitution of the Pseudomonas aeruginosa high affinity branched-chain amino acid transport system. The Journal of biological chemistry. 267(30): 21313-8. PMID: 1400443

3. Nunn, R S., et al., 1992. Purification and crystallization of the light harvesting LH1 complex from Rhodobacter sphaeroides. Journal of molecular biology. 228(4): 1259-62. PMID: 1474590

4. Lorber, B., et al., 1990. Purification of octyl beta-D-glucopyranoside and re-estimation of its micellar size. Biochimica et biophysica acta. 1023(2): 254-65. PMID: 2328249

5. Jopski, B., et al., 1989. Preparation of hemoglobin-containing liposomes using octyl glucoside and octyltetraoxyethylene. Biochimica et biophysica acta. 978(1): 79-84. PMID: 2914131

6. Gould, R J., et al., 1981. Effects of octyl beta-glucoside on insulin binding to solubilized membrane receptors. Biochemistry. 20(24): 6776-81. PMID: 7032581

7. Camm, E L., et al., 1981. Widespread distribution of some minor chlorophyll-protein complexes in some plants and algae. Plant physiology. 67(5): 1061-3. PMID: 16661784

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (100 mg/ml), methanol, and chloroform(warm).
Storage :
Store at 4° C
Melting Point :
103-104° C
Boiling Point :
454.11° C at 760 mmHg (Predicted)
Density :
1.19 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
Optical Activity :
α20D -27±3, c = 1 in methanol; α20D -31, c = 2 in methanol; α20D -28.33, c = 5 in water
IC50 :
BK polyomavirus: EC5050 >100 µM
pK Values :
pKa: 12.95 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
62852
Merck Index :
14: 6767
MDL Number :
MFCD00063288
EC Number :
249-887-8
Beilstein Registry :
84118
SMILES :
CCCCCCCCOC1C(C(C(C(O1)CO)O)O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 4 out of 5 by from Purchased raw material My company bought this material and worked out great.
Date published: 2020-08-03
Rated 5 out of 5 by from Various publications cite the use of the Various publications cite the use of the nonionic detergent n-Octyl- -D-glucopyranoside for solubilizing membrane bound proteins in their native state and for the preparation of lipid vesicles. Because of its high critical micelle concentration (20-25 mM), n-Octyl- -D-glucopyranoside has the additional advantage of being removed easily by dialysis when compared to bile salts. -SCBT Publication Review
Date published: 2015-07-14
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