Molecular structure of N,N′-Diisopropylcarbodiimide, CAS Number: 693-13-0
N,N′-Diisopropylcarbodiimide (CAS 693-13-0)
Alternate Names:
DIPCI; DIC
Application:
N,N′-Diisopropylcarbodiimide is a reagent for peptide synthesis
CAS Number:
693-13-0
Purity:
≥98%
Molecular Weight:
126.20
Molecular Formula:
C7H14N2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
N,N′-Diisopropylcarbodiimide (DIC) is an alternative to dicyclohexylcarbodiimide in peptide synthesis. It acts as a dehydrating agent in organic synthesis. It reacts with an amine or carboxylic acid to form a stable carbamate or carboxylic acid anhydride, respectively. This reaction is reversible and can be used to synthesize peptides and other organic compounds. N,N′-Diisopropylcarbodiimide is a versatile reagent used in organic synthesis and as a catalyst in many reactions. It is widely used in the synthesis of peptides, peptidomimetics, and other organic compounds.
N,N′-Diisopropylcarbodiimide (CAS 693-13-0) References
- C-H activation motivated by N,N'-diisopropylcarbodiimide within a lutetium complex stabilized by an amino-phosphine ligand. | Liu, B., et al. 2007. Dalton Trans. 4252-4. PMID: 17893812
- Divalent lanthanide complexes: highly active precatalysts for the addition of N-H and C-H bonds to carbodiimides. | Du, Z., et al. 2008. J Org Chem. 73: 8966-72. PMID: 18937411
- Ytterbium triflate: a highly active catalyst for addition of amines to carbodiimides to N,N',N''-trisubstituted guanidines. | Zhu, X., et al. 2009. J Org Chem. 74: 6347-9. PMID: 19621891
- Unexpectedly convenient and stereoselective synthesis of 4α-acyloxy-2-chloropodophyllotoxins in the presence of BF₃ ·Et₂O. | Xu, H., et al. 2011. Bioorg Med Chem Lett. 21: 4008-12. PMID: 21632246
- Solid-phase submonomer synthesis of peptoid polymers and their self-assembly into highly-ordered nanosheets. | Tran, H., et al. 2011. J Vis Exp. e3373. PMID: 22083233
- M4(CH2)4 cubane-type rare-earth methylidene complexes: unique reactivity toward unsaturated C-O, C-N, and C-S bonds. | Li, T., et al. 2012. Chemistry. 18: 15079-85. PMID: 23059833
- Combinatorial synthesis of a series of alkyl/alkenylacyloxy derivatives at the C-28 position of toosendanin as insecticidal agents. | Zhang, J., et al. 2013. Comb Chem High Throughput Screen. 16: 394-9. PMID: 23305141
- Dinuclear zinc hydride supported by an anionic bis(N-heterocyclic carbene) ligand. | Rit, A., et al. 2014. Chem Asian J. 9: 612-9. PMID: 25202771
- Alcohol cross-coupling for the kinetic resolution of diols via oxidative esterification. | Hofmann, C., et al. 2015. J Org Chem. 80: 1972-8. PMID: 25569106
- Structural and Mechanistic Insights into s-Block Bimetallic Catalysis: Sodium Magnesiate-Catalyzed Guanylation of Amines. | De Tullio, M., et al. 2016. Chemistry. 22: 17646-17656. PMID: 27786387
- Alanine scan-guided synthesis and biological evaluation of analogues of culicinin D, a potent anticancer peptaibol. | Kavianinia, I., et al. 2020. Bioorg Med Chem Lett. 30: 127135. PMID: 32229061
- Magnesium hydrides bearing sterically demanding amidinate ligands: synthesis, reactivity and catalytic application. | Bakewell, C. 2020. Dalton Trans. 49: 11354-11360. PMID: 32766619
- Ambiphilic Al-Cu Bonding. | Liu, HY., et al. 2021. Angew Chem Int Ed Engl. 60: 14390-14393. PMID: 33899319
- Inducing Nucleophilic Reactivity at Beryllium with an Aluminyl Ligand. | Boronski, JT., et al. 2023. J Am Chem Soc. 145: 4408-4413. PMID: 36786728
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N,N′-Diisopropylcarbodiimide, 5 g | sc-255380 | 5 g | $39.00 | |||
N,N′-Diisopropylcarbodiimide, 25 g | sc-255380A | 25 g | $75.00 | |||
N,N′-Diisopropylcarbodiimide, 500 g | sc-255380B | 500 g | $260.00 |