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N-Nitrosodibenzylamine (CAS 5336-53-8)

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Alternate Names:
N-Nitroso-N-(phenylmethyl)benzenemethanamine; Dibenzylnitrosamine; N,N-Dibenzylnitrosamine
Application:
N-Nitrosodibenzylamine is a mutagenic to Salmonella typhimurium
CAS Number:
5336-53-8
Molecular Weight:
226.27
Molecular Formula:
C14H14N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N-Nitrosodibenzylamine is a mutagenic to Salmonella typhimurium and induces DNA strand breaks in isolated hepatocytes. N-Nitrosodibenzylamine is a chemical compound known for its genotoxic properties. It is used in analytical methods for the detection and quantification of amines, as well as in the synthesis of sodium salts. A recent investigation focused on the matrix effect, which refers to the variation in response observed when comparing samples dissolved in organic solvents versus aqueous solutions. Multi-walled carbon nanotubes (MWCNTs) were studied in this context, and the findings revealed a pronounced matrix effect associated with MWCNTs compared to alternative solvents. The study demonstrated the higher nitrosamine adsorption capacity of MWNTs in comparison to other solvents.


N-Nitrosodibenzylamine (CAS 5336-53-8) References

  1. Identification of extractable substances from rubber nettings used to package meat products.  |  Bouma, K. and Schothorst, RC. 2003. Food Addit Contam. 20: 300-7. PMID: 12623656
  2. Assay-specific genotoxicity of N-nitrosodibenzylamine to the rat liver in vivo.  |  Schmezer, P., et al. 1990. Environ Mol Mutagen. 15: 190-7. PMID: 2192883
  3. Evaluation of genotoxicity of N-nitrosodibenzylamine in Chinese hamster V79 cells and in Salmonella.  |  Boyes, BG., et al. 1990. Mutat Res. 241: 379-85. PMID: 2377174
  4. DNA damage induced by N-nitrosodibenzylamine and N-nitroso-alpha-acetoxybenzyl-benzylamine in mammalian cell systems and in vivo.  |  Appel, KE., et al. 1990. Toxicol Lett. 52: 269-77. PMID: 2389257
  5. Determination of non-volatile N-nitrosamines in baby bottle rubber nipples and pacifiers by high-performance liquid chromatography-thermal energy analysis.  |  Sen, NP., et al. 1989. J Chromatogr. 463: 419-28. PMID: 2708488
  6. Kinetic study on the nitrosation of dibenzylamine in a model system.  |  Ayala, NL., et al. 1994. Food Chem Toxicol. 32: 1015-9. PMID: 7959455
  7. Gas chromatographic/thermal energy analyzer method for N-nitrosodibenzylamine in hams processed in elastic rubber netting.  |  Pensabene, JW. and Fiddler, W. 1994. J AOAC Int. 77: 981-4. PMID: 8069131
  8. Persistent proliferation of normal hepatocytes and promotion of preneoplastic development by N-nitrosodibenzylamine in rats.  |  Blaszyk, H., et al. 1993. J Cancer Res Clin Oncol. 120: 71-5. PMID: 8270612
  9. Dealkylation of N-nitrosodibenzylamine by metalloporphyrin/oxidant model systems for cytochrome P450.  |  Okochi, E. and Mochizuki, M. 1995. Chem Pharm Bull (Tokyo). 43: 2173-6. PMID: 8582020
  10. N-nitrosodibenzylamine in boneless hams processed in elastic rubber nettings.  |  Fiddler, W., et al. 1997. J AOAC Int. 80: 353-8. PMID: 9086591
  11. Analysis of tissue-specific lacZ mutations induced by N-nitrosodibenzylamine in transgenic mice.  |  Jiao, J., et al. 1997. Carcinogenesis. 18: 2239-45. PMID: 9395227
  12. Rapid semi-quantitative estimation of N-nitrosodibutylamine and N-nitrosodibenzylamine in smoked hams by solid-phase microextraction followed by gas chromatography-thermal energy analysis.  |  Sen, NP., et al. 1997. J Chromatogr A. 788: 131-40. PMID: 9419875
  13. Statistical analysis of lacZ mutant frequency data from MutaMouse mutagenicity assays.  |  Fung, KY., et al. 1998. Mutagenesis. 13: 249-55. PMID: 9643583

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-Nitrosodibenzylamine, 10 mg

sc-208053A
10 mg
$271.00

N-Nitrosodibenzylamine, 50 mg

sc-208053
50 mg
$394.00