Molecular structure of N-Nitrosobis(2-hydroxypropyl)amine, CAS Number: 53609-64-6
N-Nitrosobis(2-hydroxypropyl)amine (CAS 53609-64-6)
Alternate Names:
1,1-(Nitrosoimino)bis-2-propanol; 2,2-Dihydroxydipropylnitrosamine; DHPN
Application:
N-Nitrosobis(2-hydroxypropyl)amine is It shows carcinogenicity in the duct cells.
CAS Number:
53609-64-6
Purity:
≥98%
Molecular Weight:
162.19
Molecular Formula:
C6H14N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-Nitrosobis(2-hydroxypropyl)amine shows carcinogenicity in duct cells. N-Nitrosobis(2-hydroxypropyl)amine (NBHPA) is an extensively utilized organic compound within scientific research. Classified as a nitroso compound, N-Nitrosobis(2-hydroxypropyl)amine arises from the interaction between a nitrosyl group and an organic amine. Its versatile employment encompasses diverse scientific realms: functioning as a reagent in organic syntheses, serving as a tool for scrutinizing enzyme-catalyzed reactions. Although the precise workings of N-Nitrosobis(2-hydroxypropyl)amine remain incompletely elucidated, the prevailing notion centers on its capacity to bind with specific cellular proteins. This initiates a chain reaction of biochemical processes, triggering enzyme activation, inhibition, and the generation of reactive oxygen species (ROS).
N-Nitrosobis(2-hydroxypropyl)amine (CAS 53609-64-6) References
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- Ki-ras activation in pancreatic carcinomas of Syrian hamsters induced by N-nitrosobis(2-hydroxypropyl)amine. | Ushijima, T., et al. 1991. Jpn J Cancer Res. 82: 965-8. PMID: 1657847
- Hypermethylation of the Dal-1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. | Tsujiuchi, T., et al. 2007. Mol Carcinog. 46: 819-23. PMID: 17415786
- Alterations of the LKB1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. | Tajiri, M., et al. 2010. Pathobiology. 77: 225-9. PMID: 20616618
- Initiation activity of endogenously synthesized N-nitrosobis(2-hydroxypropyl)amine in the rat liver. | Yamamoto, K., et al. 1989. Cancer Lett. 45: 221-5. PMID: 2471584
- Carcinogenic activity of endogenously synthesized N-nitrosobis(2-hydroxypropyl)amine in rats administered bis(2-hydroxypropyl)amine and sodium nitrite. | Yamamoto, K., et al. 1989. Carcinogenesis. 10: 1607-11. PMID: 2766455
- Carcinogenicity of N-nitrosobis(2-hydroxypropyl)amine and N-nitrosobis(2-oxopropyl)amine in MRC rats. | Pour, P., et al. 1979. J Natl Cancer Inst. 63: 181-90. PMID: 286828
- Carcinogenic potency of N-nitrosomethyl(2-hydroxypropyl)amine and other metabolic relatives of N-nitrosobis(2-hydroxypropyl)amine by single intraperitoneal injection on the lung of rats. | Yokose, Y., et al. 1988. Jpn J Cancer Res. 79: 698-704. PMID: 3137196
- Carcinogenicity of N-nitrosobis (2-hydroxypropyl) amine after administration to Syrian hamster skin. | Pour, PM. and Stepan, K. 1985. Cancer Lett. 27: 305-8. PMID: 4016724
- Prostatic cancer induced in MRC rats by N-nitrosobis(2-oxopropyl)-amine and N-nitrosobis(2-hydroxypropyl)amine. | Pour, PM. 1983. Carcinogenesis. 4: 49-55. PMID: 6185248
- Mutagenicity of N-nitrosobis(2-hydroxypropyl)amine and its related compounds in the presence of rat lung and liver S9. | Mori, Y., et al. 1983. Cancer Lett. 18: 271-5. PMID: 6406040
- Comparison of the carcinogenic effectiveness of N-nitrosobis(2-hydroxypropyl)amine, N-nitrosobis(2-oxopropyl)amine, N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine, and N-nitroso-2,6-dimethylmorpholine in Syrian hamsters. | Lijinsky, W., et al. 1984. J Natl Cancer Inst. 72: 685-8. PMID: 6583451
- Initiation of hepatocarcinogenesis by endogenously formed N-nitrosobis(2-hydroxypropyl)amine, N-nitrosodiethanolamine and N-nitroso-2,6-dimethylmorpholine in rats. | Yamamoto, K., et al. 1995. Carcinogenesis. 16: 2633-6. PMID: 7586178
- High mutagenic activity of N-nitrosobis(2-oxopropyl)amine and N-nitrosobis(2-hydroxypropyl)amine in the host-mediated assay in hamsters: evidence for premutagenic methyl and hydroxylpropyl adducts. | Guttenplan, JB. and Kokkinakis, D. 1993. Carcinogenesis. 14: 1621-5. PMID: 8353845
- Induction of epithelial neoplasms by local application of N-nitrosobis(2-hydroxypropyl)amine and N-nitrosobis(2-acetoxypropyl)amine. | Pour, P., et al. 1977. Cancer Lett. 3: 109-13. PMID: 902248
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Nitrosobis(2-hydroxypropyl)amine, 100 mg | sc-208052 | 100 mg | $352.00 | |||
N-Nitrosobis(2-hydroxypropyl)amine, 500 mg | sc-208052A | 500 mg | $1474.00 | |||
N-Nitrosobis(2-hydroxypropyl)amine, 1 g | sc-208052B | 1 g | $2453.00 | |||
N-Nitrosobis(2-hydroxypropyl)amine, 10 g | sc-208052C | 10 g | $11735.00 |