N,N,N′,N′-Tetramethylphosphorodiamidic chloride (CAS 1605-65-8)
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N,N,N′,N′-Tetramethylphosphorodiamidic chloride functions as a phosphorylating agent in organic synthesis. It acts as a reagent in the phosphorylation of alcohols, amines, and carboxylic acids to form phosphate esters, phosphoramidates, and phosphonates. The mechanism of action involves the activation of the hydroxyl or amino group of the substrate, followed by the transfer of the phosphoryl group from the phosphorodiamidic chloride to the substrate, resulting in the formation of the desired phosphorylated product. N,N,N′,N′-Tetramethylphosphorodiamidic Chloride plays a role in facilitating the formation of phosphorus-containing compounds. At the molecular level, it interacts with specific functional groups of the substrate, leading to the introduction of the phosphoryl group and the subsequent formation of the desired phosphorylated compound.
N,N,N′,N′-Tetramethylphosphorodiamidic chloride (CAS 1605-65-8) References
- Phosphotyrosine prodrugs: design, synthesis and anti-STAT3 activity of ISS-610 aryloxy triester phosphoramidate prodrugs. | Miccoli, A., et al. 2019. Medchemcomm. 10: 200-208. PMID: 30881608
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N,N,N′,N′-Tetramethylphosphorodiamidic chloride, 10 g | sc-228785 | 10 g | $71.00 |