Date published: 2025-10-18

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N,N-Dimethylaniline (CAS 121-69-7)

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CAS Number:
121-69-7
Purity:
99%
Molecular Weight:
121.18
Molecular Formula:
C8H11N
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N,N-Dimethylaniline is a chemical compound that functions as a catalyst in various chemical reactions. It acts as a nucleophilic catalyst, participating in reactions such as acylation, alkylation, and condensation. The mechanism of action involves the formation of a complex with the substrate, leading to the activation of specific functional groups and facilitating the desired chemical transformation. N,N-Dimethylaniline is for its ability to promote reactions under mild conditions, making it useful in the synthesis of organic compounds. N,N-Dimethylaniline plays a role in facilitating the formation of new chemical bonds and promoting the rearrangement of molecular structures. Its mechanism of action involves the interaction with specific reaction intermediates, leading to the acceleration of the desired chemical processes.


N,N-Dimethylaniline (CAS 121-69-7) References

  1. Lipoxygenase-mediated hydrogen peroxide-dependent N-demethylation of N,N-dimethylaniline and related compounds.  |  Hover, CG. and Kulkarni, AP. 2000. Chem Biol Interact. 124: 191-203. PMID: 10728778
  2. Simultaneous determination of N,N-dimethylaniline and phenol in wastewater by high-performance liquid chromatography with chemiluminescence detection.  |  Huang, C., et al. 2005. Anal Sci. 21: 565-7. PMID: 15913149
  3. Meta-metallation of N,N-dimethylaniline: Contrasting direct sodium-mediated zincation with indirect sodiation-dialkylzinc co-complexation.  |  Armstrong, DR., et al. 2011. Beilstein J Org Chem. 7: 1234-48. PMID: 21977208
  4. Oxidative N-demethylation of N,N-dimethylaniline by purified isozymes of cytochrome P-450.  |  Pandey, RN., et al. 1989. Biochem Pharmacol. 38: 2181-5. PMID: 2500128
  5. Ultraviolet relaxation dynamics of aniline, N, N-dimethylaniline and 3,5-dimethylaniline at 250 nm.  |  Thompson, JO., et al. 2015. J Chem Phys. 142: 114309. PMID: 25796251
  6. The metabolism of N,N-dimethylaniline by isolated rat hepatocytes: identification of a novel N-conjugate.  |  Sherratt, AJ. and Damani, LA. 1989. Xenobiotica. 19: 379-88. PMID: 2750202
  7. Conversion of N,N-dimethylaniline to N,N-dimethylaniline-N-oxide by a cytosolic flavin-containing enzyme from Trypanosoma cruzi.  |  Agosin, M. and Ankley, GT. 1987. Drug Metab Dispos. 15: 200-3. PMID: 2882978
  8. Friedel-Crafts Reaction of N,N-Dimethylaniline with Alkenes Catalyzed by Cyclic Diaminocarbene-Gold(I) Complex.  |  Wu, H., et al. 2018. Sci Rep. 8: 11449. PMID: 30061755
  9. Slow photoionization via higher excited states of N,N-dimethylaniline in ethanol solution probed by femtosecond transient absorption spectroscopy under two-pulse two-photon excitation.  |  Koga, M., et al. 2021. J Chem Phys. 154: 054304. PMID: 33557537
  10. Identification of novel neuroprotective N,N-dimethylaniline derivatives that prevent oxytosis/ferroptosis and localize to late endosomes and lysosomes.  |  Hirata, Y., et al. 2021. Free Radic Biol Med. 174: 225-235. PMID: 34407426
  11. Effect of ferroptosis inhibitors oxindole-curcumin hybrid compound and N,N-dimethylaniline derivatives on rotenone-induced oxidative stress.  |  Hirata, Y., et al. 2022. Eur J Pharmacol. 928: 175119. PMID: 35753403
  12. Recombination of X-ray-Generated Radical Ion Pairs in Alkane Solution Assembles Optically Inaccessible Exciplexes from a Series of Perfluorinated para-Oligophenylenes with N,N-Dimethylaniline.  |  Nikul'shin, PV., et al. 2023. Int J Mol Sci. 24: PMID: 37108728
  13. The in vitro metabolism of N,N-dimethylaniline by guinea pig and rabbit tissue preparations.  |  Gorrod, JW. and Gooderham, NJ. 1981. Eur J Drug Metab Pharmacokinet. 6: 195-206. PMID: 7308239
  14. Genotoxicity analysis of N,N-dimethylaniline and N,N-dimethyl-p-toluidine.  |  Taningher, M., et al. 1993. Environ Mol Mutagen. 21: 349-56. PMID: 8491214

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N,N-Dimethylaniline, 100 ml

sc-215496
100 ml
$28.00

N,N-Dimethylaniline, 1 L

sc-215496A
1 L
$97.00