Date published: 2025-10-17

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N-Methyl-N-(trimethylsilyl)trifluoroacetamide (CAS 24589-78-4)

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Alternate Names:
N-Trimethylsilyl-N-methyl trifluoroacetamide; MSTFA; N-methyl-N-trimethylsilyltrifluoroacetamide
Application:
N-Methyl-N-(trimethylsilyl)trifluoroacetamide is silylating agent that forms volatile derivatives for GC-MS analysis
CAS Number:
24589-78-4
Purity:
≥97%
Molecular Weight:
199.25
Molecular Formula:
C6H12F3NOSi
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a versatile, non-volatile, and non-toxic reagent that finds extensive use in laboratory experiments and applications. N-Methyl-N-(trimethylsilyl)trifluoroacetamide plays a role in various scientific research domains, encompassing organic synthesis, analytical chemistry, and biochemistry. In organic synthesis, N-Methyl-N-(trimethylsilyl)trifluoroacetamide serves as a valuable reagent for synthesizing diverse organic compounds, including amines, carboxylic acids, and alcohols. In analytical chemistry, it acts as a solvent, enabling the analysis of various compounds such as proteins and metabolites. In the realm of biochemistry, N-Methyl-N-(trimethylsilyl)trifluoroacetamide serves as a critical reagent for synthesizing various biomolecules like peptides, nucleic acids, and carbohydrates.


N-Methyl-N-(trimethylsilyl)trifluoroacetamide (CAS 24589-78-4) References

  1. Investigation of the silylation of ephedrines using N-methyl-N-trimethylsilyl-trifluoroacetamide.  |  Forsdahl, G. and Gmeiner, G. 2004. J Chromatogr B Analyt Technol Biomed Life Sci. 811: 201-8. PMID: 15522721
  2. Analysis of sibutramine metabolites as N-trifluoroacetamide and O-trimethylsilyl derivatives by gas chromatography-mass spectrometry in urine.  |  Sardela, VF., et al. 2009. J Chromatogr B Analyt Technol Biomed Life Sci. 877: 3003-11. PMID: 19660994
  3. Stereospecific Derivatization of Amphetamines, Phenol Alkylamines, and Hydroxyamines and Quantification of the Enantiomers by Capillary GC/MS.  |  Shin, HS. and Donike, M. 1996. Anal Chem. 68: 3015-20. PMID: 21619369
  4. Determination of naproxen in human plasma by GC-MS.  |  Yilmaz, B., et al. 2014. J Sep Sci. 37: 997-1003. PMID: 24478225
  5. Determination of flurbiprofen in human plasma by gas chromatography with mass spectrometry and its pharmacokinetics.  |  Yilmaz, B., et al. 2014. J AOAC Int. 97: 1061-6. PMID: 25145138
  6. Fatty Acid Structure and Degradation Analysis in Fingerprint Residues.  |  Pleik, S., et al. 2016. J Am Soc Mass Spectrom. 27: 1565-74. PMID: 27324649
  7. Solid-phase analytical derivatization for gas-chromatography-mass-spectrometry-based metabolomics.  |  Takeo, E., et al. 2017. J Biosci Bioeng. 124: 700-706. PMID: 28800906
  8. Preparation and structural characterization of regioselective 4-O/6-O-desulfated chondroitin sulfate.  |  Han, W., et al. 2018. Carbohydr Res. 460: 8-13. PMID: 29476992
  9. A Novel Bioanalytical Method for the Determination of Opioids in Blood and Pericardial Fluid.  |  Ferreira, E., et al. 2020. J Anal Toxicol. 44: 754-768. PMID: 32518955
  10. Determination of Selected Cathinones in Blood by Solid-Phase Extraction and GC-MS.  |  Antunes, M., et al. 2021. J Anal Toxicol. 45: 233-242. PMID: 32588896
  11. Analysis of hydroxylated phenylalkylamine stimulants in urine by GC-APPI-HRMS.  |  Bressan, C., et al. 2020. Anal Bioanal Chem. 412: 7837-7850. PMID: 32954468
  12. Simultaneous quantification of caffeine and its main metabolites by gas chromatography mass spectrometry in horse urine.  |  Göktaş, EF., et al. 2022. Biomed Chromatogr. 36: e5445. PMID: 35797186
  13. Rapid and Reliable Quantification of Glycerol-3-phosphate Using Gas Chromatography-coupled Mass Spectrometry.  |  Liu, H., et al. 2023. Bio Protoc. 13: e4645. PMID: 37056243

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-Methyl-N-(trimethylsilyl)trifluoroacetamide, 1 ml

sc-255359
1 ml
$14.00

N-Methyl-N-(trimethylsilyl)trifluoroacetamide, 5 ml

sc-255359A
5 ml
$54.00