Molecular structure of N-Desmethyl Diltiazem Hydrochloride, CAS Number: 130606-60-9
N-Desmethyl Diltiazem Hydrochloride (CAS 130606-60-9)
Alternate Names:
N-Demethyldiltiazem; N-Monodesmethyldiltiazem
Application:
N-Desmethyl Diltiazem Hydrochloride is a calcium channel blocker
CAS Number:
130606-60-9
Molecular Weight:
436.95
Molecular Formula:
C21H24N2O4S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
N-Desmethyl Diltiazem Hydrochloride is a metabolite of Diltiazem (sc-204726), a non-dihydropyridine calcium channel blocker. Studies show that N-Desmethyl Diltiazem Hydrochloride selectively inhibits CYP3A4. This enzyme is useful in a variety of cellular reactions such as the oxidation of xenobiotics. In addition, N-Desmethyl Diltiazem Hydrochloride inhibits testosterone 6beta-hydroxylation which is mediated by CYP3A4. Although Diltiazem acts as an inhibitor of CYP3A4, it can also be metabolized by the enzyme. It is known that Diltiazem acts as a vasodilator increasing blood flow around peripheral and coronary vessels.
N-Desmethyl Diltiazem Hydrochloride (CAS 130606-60-9) References
- An in vitro model for predicting in vivo inhibition of cytochrome P450 3A4 by metabolic intermediate complex formation. | Mayhew, BS., et al. 2000. Drug Metab Dispos. 28: 1031-7. PMID: 10950845
- Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites. | Sutton, D., et al. 1997. J Pharmacol Exp Ther. 282: 294-300. PMID: 9223567
Inhibitor of:
CYP3A4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Desmethyl Diltiazem Hydrochloride, 10 mg | sc-219119 | 10 mg | $410.00 | |||
N-Desmethyl Diltiazem Hydrochloride, 25 mg | sc-219119A | 25 mg | $890.00 | |||
N-Desmethyl Diltiazem Hydrochloride, 50 mg | sc-219119B | 50 mg | $1503.00 | |||
N-Desmethyl Diltiazem Hydrochloride, 100 mg | sc-219119C | 100 mg | $2400.00 |