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N-Demethyl Mifepristone (CAS 104004-96-8)

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Alternate Names:
(11β,17β)-17-Hydroxy-11-[4-(methylamino)phenyl]-17-(1-propyn-1-yl)-estra-4,9-dien-3-one; N-Desmethyl-RU 486; RU 42633
Application:
N-Demethyl Mifepristone is a metabolite of Mifepristone
CAS Number:
104004-96-8
Molecular Weight:
415.57
Molecular Formula:
C28H33NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N-Demethyl Mifepristone (DMF) is a metabolite of Mifepristone. It is a synthetic progestin derivative of mifepristone that is structurally related to the steroid hormone progesterone. N-Demethyl Mifepristone is a potent antagonist of the progesterone receptor and acts as an agonist of the glucocorticoid receptor. This compound has been used in laboratory experiments to study the physiological and biochemical effects of progesterone and its derivatives. For example, it has been employed to investigate the effects of progesterone on the reproductive system, the development of embryos, the endometrium, and the uterus.


N-Demethyl Mifepristone (CAS 104004-96-8) References

  1. Synthesis of N-desmethyl derivatives of 17alpha-acetoxy-11beta-(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-die ne-3,20-dione and mifepristone1: substrates for the synthesis of radioligands.  |  Rao, PN., et al. 1999. Steroids. 64: 205-12. PMID: 10400381
  2. In vitro metabolism of mifepristone (RU-486) in rat, monkey and human hepatic S9 fractions: identification of three new mifepristone metabolites.  |  Wu, WN., et al. 1999. Xenobiotica. 29: 1089-100. PMID: 10598744
  3. Simultaneous determination of mifepristone and monodemethyl-mifepristone in human plasma by liquid chromatography-tandem mass spectrometry method using levonorgestrel as an internal standard: application to a pharmacokinetic study.  |  Tang, C., et al. 2009. Biomed Chromatogr. 23: 71-80. PMID: 18816505
  4. Relative binding affinity of various progestins and antiprogestins to a rabbit myometrium receptor.  |  Boonkasemsanti, W., et al. 1989. Arzneimittelforschung. 39: 195-9. PMID: 2730687
  5. Analysis of the relation between receptor binding affinity and antagonist efficacy of antiglucocorticoids.  |  Gagne, D., et al. 1986. J Steroid Biochem. 25: 315-22. PMID: 2877119
  6. Mifepristone Treatment Promotes Testicular Leydig Cell Tumor Progression in Transgenic Mice.  |  Ponikwicka-Tyszko, D., et al. 2020. Cancers (Basel). 12: PMID: 33158280
  7. Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes.  |  Jang, GR., et al. 1996. Biochem Pharmacol. 52: 753-61. PMID: 8765473

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-Demethyl Mifepristone, 1 mg

sc-208018
1 mg
$336.00

N-Demethyl Mifepristone, 5 mg

sc-208018A
5 mg
$663.00

N-Demethyl Mifepristone, 10 mg

sc-208018B
10 mg
$1022.00

N-Demethyl Mifepristone, 25 mg

sc-208018C
25 mg
$1390.00

N-Demethyl Mifepristone, 50 mg

sc-208018D
50 mg
$1999.00

N-Demethyl Mifepristone, 100 mg

sc-208018E
100 mg
$3988.00

N-Demethyl Mifepristone, 1 g

sc-208018F
1 g
$24490.00