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n-Butoxyacetic acid (CAS 2516-93-0)

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Alternate Names:
2-Butoxyacetic acid
CAS Number:
2516-93-0
Purity:
≥95%
Molecular Weight:
132.16
Molecular Formula:
C6H12O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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n-Butoxyacetic acid, also known as 2-butoxyethanoic acid, is a carboxylic acid. It manifests as a colorless liquid that readily dissolves in water, emitting a strong and unpleasant odor. n-Butoxyacetic acid serves as a component in the production of various organic compounds, including esters, amides, and amines. Furthermore, it fulfills the role of a stabilizer and preservative in numerous products. n-Butoxyacetic acid possesses characteristics of a weak acid, showcasing its ability to function as both an acid and a base. In its acidic form, it acts as an acid catalyst, promoting the formation of esters, amides, and amines. Conversely, in its basic form, it exhibits nucleophilic behavior, enabling it to react with electrophiles, forming covalent bonds and contributing to various chemical reactions.


n-Butoxyacetic acid (CAS 2516-93-0) References

  1. New methods for determination of 2-butoxyethanol, butoxyacetaldehyde and butoxyacetic acid in aqueous systems, with special reference to cell culture conditions.  |  Hildenbrand, S., et al. 2000. Arch Toxicol. 74: 72-8. PMID: 10839473
  2. Mechanisms of 2-butoxyethanol carcinogenicity: studies on Syrian Hamster Embryo (SHE) cell transformation.  |  Park, J., et al. 2002. Toxicol Sci. 68: 43-50. PMID: 12075109
  3. Synthesis, characterization, and use of 2-[(2H(9))butoxy]acetic acid and 2-(3-methylbutoxy)acetic acid as an internal standard and an instrument performance surrogate, respectively, for the gas chromatographic-mass spectrometric determination of 2-butoxyacetic acid, a human metabolite of 2-butoxyethanol.  |  Brown, KK., et al. 2003. J Chromatogr B Analyt Technol Biomed Life Sci. 792: 153-66. PMID: 12860023
  4. A human exposure study to investigate biological monitoring methods for 2-butoxyethanol.  |  Jones, K. and Cocker, J. 2003. Biomarkers. 8: 360-70. PMID: 14602521
  5. Free and total urinary 2-butoxyacetic acid following dermal and inhalation exposure to 2-butoxyethanol in human volunteers.  |  Kezic, S., et al. 2004. Int Arch Occup Environ Health. 77: 580-6. PMID: 15688250
  6. Mechanisms of 2-butoxyethanol-induced hemangiosarcomas.  |  Corthals, SM., et al. 2006. Toxicol Sci. 92: 378-86. PMID: 16675516
  7. Development of a gas chromatographic test for the quantitation of the biomarker 2-butoxyacetic acid in urine samples.  |  B'Hymer, C. 2007. J Chromatogr Sci. 45: 422-7. PMID: 17725869
  8. Biological monitoring of low-level 2-butoxyethanol exposure in decal transfer workers in bicycle manufacturing factories.  |  Hung, PC., et al. 2011. Occup Environ Med. 68: 777-82. PMID: 21278143
  9. Comparison of the in vivo and in vitro testicular effects produced by methoxy-, ethoxy- and N-butoxy acetic acids in the rat.  |  Foster, PM., et al. 1987. Toxicology. 43: 17-30. PMID: 3810650
  10. n-Butoxyacetic acid, a urinary metabolite from inhaled n-butoxyethanol (Butylcellosolve).  |  Jönsson, AK. and Steen, G. 1978. Acta Pharmacol Toxicol (Copenh). 42: 354-6. PMID: 581030
  11. Physiologically based pharmacokinetics of 2-butoxyethanol and its major metabolite, 2-butoxyacetic acid, in rats and humans.  |  Corley, RA., et al. 1994. Toxicol Appl Pharmacol. 129: 61-79. PMID: 7974497
  12. Inhalation toxicokinetics of butoxyethanol and its metabolite butoxyacetic acid in the male Sprague-Dawley rat.  |  Johanson, G. 1994. Arch Toxicol. 68: 588-94. PMID: 7998827
  13. Hemolysis and deformability of erythrocytes exposed to butoxyacetic acid, a metabolite of 2-butoxyethanol: II. Resistance in red blood cells from humans with potential susceptibility.  |  Udden, MM. 1994. J Appl Toxicol. 14: 97-102. PMID: 8027514
  14. Assessment of the haemolytic activity of 2-butoxyethanol and its major metabolite, butoxyacetic acid, in various mammals including humans.  |  Ghanayem, BI. and Sullivan, CA. 1993. Hum Exp Toxicol. 12: 305-11. PMID: 8104009
  15. Toxicokinetics of inhaled 2-butoxyethanol and its major metabolite, 2-butoxyacetic acid, in F344 rats and B6C3F1 mice.  |  Dill, JA., et al. 1998. Toxicol Appl Pharmacol. 153: 227-42. PMID: 9878593

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

n-Butoxyacetic acid, 1 g

sc-269813
1 g
$122.00