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N-Acetylneuraminic Acid, 2,3-Dehydro-2-deoxy-, Sodium Salt (CAS 24967-27-9)

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Application:
N-Acetylneuraminic Acid, 2,3-Dehydro-2-deoxy-, Sodium Salt is a bacterial, viral, and mammalian neuraminidase inhibitor
CAS Number:
24967-27-9
Purity:
≥95%
Molecular Weight:
313.24
Molecular Formula:
C11H16NNaO8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N-Acetylneuraminic acid, 2,3-dehydro-2-deoxy-, sodium salt, is a chemical compound that has attracted considerable interest in scientific research, particularly in the fields of glycobiology and carbohydrate chemistry. This compound, commonly referred to as Neu5Ac2en, is a derivative of sialic acid, a key component of glycoproteins and glycolipids found on cell surfaces. Neu5Ac2en serves as a valuable tool for studying the biological functions and interactions of sialic acids. Scientists have utilized its structural similarities to natural sialic acids to investigate their roles in various biological processes, such as cell recognition, signal transduction, and pathogen-host interactions. Moreover, Neu5Ac2en has been employed in chemical synthesis strategies aimed at accessing structurally diverse sialic acid derivatives. Researchers have developed innovative synthetic methodologies to functionalize the unique chemical scaffold of Neu5Ac2en, allowing for the generation of novel compounds with potential biological activities or diagnostic applications. Furthermore, Neu5Ac2en has been utilized as a substrate or inhibitor in enzymatic assays aimed at elucidating the mechanisms of sialic acid-processing enzymes, such as sialyltransferases and neuraminidases. By studying the interactions between these enzymes and Neu5Ac2en, researchers gain insights into the enzymatic pathways involved in sialic acid metabolism.


N-Acetylneuraminic Acid, 2,3-Dehydro-2-deoxy-, Sodium Salt (CAS 24967-27-9) References

  1. Characterisation of an ionisable group involved in binding and catalysis by sialidase from influenza virus.  |  Chong, AK., et al. 1991. Biochem Int. 24: 165-71. PMID: 1768256
  2. Novel method for chase analysis of oligosaccharide metabolic error caused by xenobiotics.  |  Kato, T., et al. 2010. Anal Biochem. 405: 103-8. PMID: 20570645
  3. Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice.  |  Jansen, AJ., et al. 2012. Blood. 119: 1263-73. PMID: 22101895
  4. Addition of sialidase or p38 MAPK inhibitors does not ameliorate decrements in platelet in vitro storage properties caused by 4 °C storage.  |  Skripchenko, A., et al. 2014. Vox Sang. 107: 360-7. PMID: 24976248
  5. Autophagy Ameliorates Reactive Oxygen Species-Induced Platelet Storage Lesions.  |  Zhao, X., et al. 2022. Oxid Med Cell Longev. 2022: 1898844. PMID: 36046681
  6. Inhibition of sialidases from viral, bacterial and mammalian sources by analogues of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid modified at the C-4 position.  |  Holzer, CT., et al. 1993. Glycoconj J. 10: 40-4. PMID: 8358225
  7. Effects of cell surface ganglioside sialidase inhibition on growth control and differentiation of human neuroblastoma cells.  |  Kopitz, J., et al. 1997. Eur J Cell Biol. 73: 1-9. PMID: 9174666

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-Acetylneuraminic Acid, 2,3-Dehydro-2-deoxy-, Sodium Salt, 10 mg

sc-221987
10 mg
$352.00