N-5-Carboxypentyl-1-deoxynojirimycin (CAS 79206-51-2)

N-5-Carboxypentyl-1-deoxynojirimycin, a structural analog of the iminosugar deoxynojirimycin, has gained attention in biochemical and pharmacological research due to its inhibitory effects on glycosidases. Its mechanism of action involves competitive inhibition of specific glycosidases, particularly α-glucosidases and α-mannosidases, which play crucial roles in carbohydrate metabolism and glycoprotein processing. By binding to the active site of these enzymes, N-5-Carboxypentyl-1-deoxynojirimycin interferes with substrate hydrolysis, leading to the accumulation of misfolded glycoproteins within cells. This accumulation triggers cellular stress responses, including the unfolded protein response (UPR) and endoplasmic reticulum (ER) stress-mediated pathways. Consequently, researchers have utilized this compound to investigate the molecular mechanisms underlying lysosomal storage disorders (LSDs) and other glycosylation-related diseases. Furthermore, N-5-Carboxypentyl-1-deoxynojirimycin has been employed as a pharmacological tool to study the physiological functions of glycosidases and their implications in cellular homeostasis. Its ability to modulate glycosidase activity makes it a valuable resource in deciphering the intricacies of glycosylation processes and exploring potential strategies for glycosylation-related disorders.