Molecular structure of N-(1-Pyrenyl) Maleimide, CAS Number: 42189-56-0
N-(1-Pyrenyl) Maleimide (CAS 42189-56-0)
Alternate Names:
1-(1-Pyrenyl)-1H-pyrrole-2,5-dione
Application:
N-(1-Pyrenyl) Maleimide is a florescent sulfhydryl reagent
CAS Number:
42189-56-0
Molecular Weight:
297.31
Molecular Formula:
C20H11NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-(1-Pyrenyl) Maleimide is a fluorescent dye to label and visualize proteins and other biomolecules. Its mechanism of action involves covalently binding to thiol groups on proteins, resulting in the formation of a stable fluorescent adduct. This allows for the visualization and tracking of the labeled proteins within cells and tissues using fluorescence microscopy or other imaging techniques. N-(1-Pyrenyl) Maleimide′s function as a fluorescent probe enables researchers to study the localization, dynamics, and interactions of specific proteins within biological systems. Its ability to selectively label and visualize proteins may be a useful reagent for investigating cellular processes and protein function.
N-(1-Pyrenyl) Maleimide (CAS 42189-56-0) References
- High performance liquid chromatography analysis of D-penicillamine by derivatization with N-(1-pyrenyl)maleimide (NPM). | Yusof, M., et al. 2000. Biomed Chromatogr. 14: 535-40. PMID: 11113937
- High performance liquid chromatography analysis of 2-mercaptoethylamine (cysteamine) in biological samples by derivatization with N-(1-pyrenyl) maleimide (NPM) using fluorescence detection. | Ogony, J., et al. 2006. J Chromatogr B Analyt Technol Biomed Life Sci. 843: 57-62. PMID: 16793352
- N-(1-Pyrenyl) maleimide inhibits telomerase activity in a cell free system and induces apoptosis in Jurkat cells. | Huang, PR., et al. 2012. Mol Biol Rep. 39: 8899-905. PMID: 22707200
- N-(1-pyrenyl) maleimide induces bak oligomerization and mitochondrial dysfunction in Jurkat Cells. | Huang, PR., et al. 2015. Biomed Res Int. 2015: 798489. PMID: 25632401
- The modifier effects of chymotrypsin and trypsin enzymes on fluorescence lifetime distribution of 'N-(1-pyrenyl)maleimide-bovine serum albumin' complex. | Özyiğit, İE., et al. 2016. Spectrochim Acta A Mol Biomol Spectrosc. 154: 8-12. PMID: 26490799
- The in vivo anti-leukemia activity of N-(1-Pyrenlyl) maleimide in a bioluminescent mouse model. | Chen, CY., et al. 2017. Leuk Res. 62: 64-69. PMID: 28987819
- The reaction of N-(1-pyrene)maleimide with sarcoplasmic reticulum. | Papp, S., et al. 1986. Biophys J. 49: 411-24. PMID: 2937461
- Bioengineering a glucose oxidase nanosensor for near-infrared continuous glucose monitoring. | Zubkovs, V., et al. 2022. Nanoscale Adv. 4: 2420-2427. PMID: 35746900
- Analysis of glutathione, glutathione disulfide, cysteine, homocysteine, and other biological thiols by high-performance liquid chromatography following derivatization by n-(1-pyrenyl)maleimide. | Winters, RA., et al. 1995. Anal Biochem. 227: 14-21. PMID: 7668373
- Comparison of Ellman's reagent with N-(1-pyrenyl)maleimide for the determination of free sulfhydryl groups in reduced cellobiohydrolase I from Trichoderma reesei. | Woodward, J., et al. 1993. J Biochem Biophys Methods. 26: 121-9. PMID: 8509600
- High-performance liquid chromatography assay for N-acetylcysteine in biological samples following derivatization with N-(1-pyrenyl)maleimide. | Ercal, N., et al. 1996. J Chromatogr B Biomed Appl. 685: 329-34. PMID: 8953175
- Cross-linking and N-(1-pyrenyl)maleimide labeling of cysteine mutants of proton-pumping pyridine nucleotide transhydrogenase of Escherichia coli. | Sedgwick, EG., et al. 1997. Biochemistry. 36: 15285-93. PMID: 9398257
- Reaction of N-(3-pyrene)maleimide with thiol groups of reticulocyte ribosomes. | Lee, T. and Heintz, RL. 1976. Eur J Biochem. 66: 105-14. PMID: 954741
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-(1-Pyrenyl) Maleimide, 100 mg | sc-211945 | 100 mg | $255.00 |