MYG1 Antibody (F-5): sc-393331

MYG1 Antibody (F-5) is a mouse monoclonal IgM antibody that detects MYG1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MYG1 antibody (F-5) is available as the non-conjugated form. MYG1, also known as Melanocyte proliferating gene 1, C12orf10, Gamm1, MYG, MST024, or MSTP024, is a 376 amino acid nucleo-mitochondrial protein that plays a crucial role in cellular processes. MYG1 is primarily located in the mitochondria and nucleus, which is significant because dual localization suggests a role in coordinating mitochondrial function and nuclear gene expression, essential for maintaining cellular homeostasis and responding to stress. MYG1 is encoded by a gene located on human chromosome 12q13.13 and is expressed ubiquitously across various tissues, with highest levels found in the testis. MYG1 features a metal-dependent protein hydrolase domain and possesses a mitochondrial targeting signal in its N-terminal region, along with a Pat7-type nuclear localization signal between amino acids 33-39. MYG1 expression varies during embryonic development, indicating involvement in early developmental processes, while stable expression in adult tissues suggests a role in stress responses and potential associations with conditions such as vitiligo.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

MYG1 Antibody (F-5) References:

1. Characterization of Trypanosoma cruzi TcRjl locus and analysis of its transcript.  |  Nepomuceno-Silva, JL., et al. 2004. Parasitology. 129: 325-33. PMID: 15471007
2. The finished DNA sequence of human chromosome 12.  |  Scherer, SE., et al. 2006. Nature. 440: 346-51. PMID: 16541075
3. MYG1, novel melanocyte related gene, has elevated expression in vitiligo.  |  Kingo, K., et al. 2006. J Dermatol Sci. 44: 119-22. PMID: 16996721
4. Characterization of MYG1 gene and protein: subcellular distribution and function.  |  Philips, MA., et al. 2009. Biol Cell. 101: 361-73. PMID: 19014353
5. Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.  |  Timpson, NJ., et al. 2009. Hum Mol Genet. 18: 1510-7. PMID: 19181680
6. Comparative proteomic analysis of an Aspergillus fumigatus mutant deficient in glucosidase I (AfCwh41).  |  Zhang, L., et al. 2009. Microbiology (Reading). 155: 2157-2167. PMID: 19389762
7. Myg1-deficient mice display alterations in stress-induced responses and reduction of sex-dependent behavioural differences.  |  Philips, MA., et al. 2010. Behav Brain Res. 207: 182-95. PMID: 19818808
8. Promoter polymorphism -119C/G in MYG1 (C12orf10) gene is related to vitiligo susceptibility and Arg4Gln affects mitochondrial entrance of Myg1.  |  Philips, MA., et al. 2010. BMC Med Genet. 11: 56. PMID: 20377893
9. Shared genetic relationships underlying generalized vitiligo and autoimmune thyroid disease.  |  Spritz, RA. 2010. Thyroid. 20: 745-54. PMID: 20578892

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MYG1 Antibody (F-5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-MYG1 Antibody (F-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MYG1 Antibody (F-5) Specifications

Alternate Product Name: MYG1

Product Clone Name: F-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 162-199

Epitope Target: MYG1

Epitope Species: human

Product Reactivity/Detection: MYG1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for MYG1 Antibody (F-5): P: Blocking Peptide