MT-21 (CAS 186379-49-7)
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MT-21 is a cell-permeable antitumor agent that induces apoptosis (~40 muM) by directly releasing cytochrome c from mitochondria in human promyelocytic leukemia HL-60 cells. Does not affect mitochondrial transmembrane potential (DeltaPsim) in any significant manner. Selectively induces neurite outgrowth in cultured SH-SY5Y, and causes apoptosis in PC12 cells. MT-21 is an activator of caspase-3, JNK and Krs. It is a synthetic compound that significantly inhibits ADP transport activity in mitochondria and reduces the binding of adenine nucleotide translocase (ANT) to a phenylarsine oxide affinity matrix. The ANT, a component of the mitochondrial permeability transition pore, is identified as the molecular target for MT-21.
MT-21 (CAS 186379-49-7) References
- Requirement of protein kinase (Krs/MST) activation for MT-21-induced apoptosis. | Watabe, M., et al. 1999. Oncogene. 18: 5211-20. PMID: 10498871
- MT-21 is a synthetic apoptosis inducer that directly induces cytochrome c release from mitochondria. | Watabe, M., et al. 2000. Cancer Res. 60: 5214-22. PMID: 11016650
- A novel adenine nucleotide translocase inhibitor, MT-21, induces cytochrome c release by a mitochondrial permeability transition-independent mechanism. | Machida, K., et al. 2002. J Biol Chem. 277: 31243-8. PMID: 12063261
- The covalent reactivity of functionalized 5-hydroxy-butyrolactams is the basis for targeting of fatty acid binding protein 5 (FABP5) by the neurotrophic agent MT-21. | Svenningsen, EB., et al. 2022. RSC Chem Biol. 3: 1216-1229. PMID: 36320884
- Neuritogenic effect of epolactaene derivatives on human neuroblastoma cells which lack high-affinity nerve growth factor receptors. | Kakeya, H., et al. 1997. J Med Chem. 40: 391-4. PMID: 9046328
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MT-21, 10 mg | sc-221959 | 10 mg | $240.00 | |||
MT-21, 50 mg | sc-221959A | 50 mg | $855.00 |