Molecular structure of MPPG, CAS Number: 169209-65-8
MPPG (CAS 169209-65-8)
Alternate Names:
(RS)-α-Methyl-4-phosphonophenylglycine
Application:
MPPG is a potent antagonist of L-AP4-induced effects
CAS Number:
169209-65-8
Molecular Weight:
245.17
Molecular Formula:
C9H12NO5P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MPPG is a potent antagonist of L-AP4-induced effects in rat spinal cord, thalamic and hippocampal neurons, showing selectivity over (1S,3S)-ACPD-induced effects. MPPG is also a potent antagonist of mGluR (mGlu receptors) linked to adenylyl cyclase in adult rat cortical slices.
MPPG (CAS 169209-65-8) References
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- Metabotropic glutamate receptor subtypes modulating neurotransmission at parallel fibre-Purkinje cell synapses in rat cerebellum. | Neale, SA., et al. 2001. Neuropharmacology. 41: 42-9. PMID: 11445184
- Synaptic plasticity in the acoustic startle pathway: the neuronal basis for short-term habituation? | Weber, M., et al. 2002. Eur J Neurosci. 16: 1325-32. PMID: 12405993
- Metabotropic glutamate receptor agonists modify the pyloric output of the crustacean stomatogastric ganglion. | Pérez-Acevedo, NL. and Krenz, WD. 2005. Brain Res. 1062: 1-8. PMID: 16256086
- New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord. | Jane, DE., et al. 1995. Neuropharmacology. 34: 851-6. PMID: 8532166
- Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices. | Bushell, TJ., et al. 1996. Br J Pharmacol. 117: 1457-62. PMID: 8730739
- Antagonism of the presumed presynaptic action of L-AP4 on GABAergic transmission in the ventrobasal thalamus by the novel mGluR antagonist MPPG. | Salt, TE. and Turner, JP. 1996. Neuropharmacology. 35: 239-41. PMID: 8734494
- Novel potent selective phenylglycine antagonists of metabotropic glutamate receptors. | Bedingfield, JS., et al. 1996. Eur J Pharmacol. 309: 71-8. PMID: 8864696
- Antagonism of mGlu receptors and potentiation of EPSCs at rat spinal motoneurones in vitro. | Cao, CQ., et al. 1997. Neuropharmacology. 36: 313-8. PMID: 9175609
- Contribution of metabotropic glutamate receptors to the depression of excitatory postsynaptic potentials during hypoxia. | de Mendonça, A. and Ribeiro, JA. 1997. Neuroreport. 8: 3667-71. PMID: 9427348
Inhibitor of:
mGluR, and mGLuR-8.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MPPG, 10 mg | sc-203143 | 10 mg | $175.00 | |||
MPPG, 50 mg | sc-203143A | 50 mg | $739.00 |