Molsidomine (CAS 25717-80-0)
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Molsidomine is an organonitrate compound extensively studied for its role in releasing nitric oxide (NO), which is of interest in cardiovascular research. The research applications of molsidomine primarily focus on its ability to act as a NO donor, where it is used in studies to understand the regulation of vascular tone and blood flow. In such research, molsidomine is often utilized to examine the molecular mechanisms underlying vasodilation. Additionally, molsidomine has been investigated in the context of its anti-inflammatory effects in various models of oxidative stress and inflammation. Its utility extends to the study of signal transduction pathways, especially concerning cyclic guanosine monophosphate (cGMP), as NO-mediated activation of guanylate cyclase leads to increased levels of cGMP, which is a significant secondary messenger in cells.
Molsidomine (CAS 25717-80-0) References
- Protective effect of the nitric oxide donor molsidomine on indomethacin and aspirin-induced gastric injury in rats. | Mourad, FH., et al. 2000. Eur J Gastroenterol Hepatol. 12: 81-4. PMID: 10656215
- Effects of molsidomine on scopolamine-induced amnesia and hypermotility in the rat. | Pitsikas, N., et al. 2001. Eur J Pharmacol. 426: 193-200. PMID: 11527544
- The nitric oxide donor molsidomine prevents ischemia/reperfusion injury of the adult rat small intestine. | Oztürk, H., et al. 2003. Pediatr Surg Int. 19: 305-8. PMID: 12783256
- Renal protective effect of molsidomine and L-arginine in ischemia-reperfusion induced injury in rats. | Chander, V. and Chopra, K. 2005. J Surg Res. 128: 132-9. PMID: 15936772
- The effects of molsidomine on hypoxia inducible factor alpha and Sonic hedgehog in testicular ischemia/reperfusion injury in rats. | Dokucu, AI., et al. 2009. Int Urol Nephrol. 41: 101-8. PMID: 18787973
- The effects of nitric oxide donor molsidomine on skeletal muscle damage in a rat hind limb model of ischemia-reperfusion. | Ozturk, K., et al. 2009. Eur Surg Res. 42: 71-7. PMID: 19005258
- The nitric oxide-donor molsidomine modulates the innate inflammatory response in a mouse model of muscular dystrophy. | Zordan, P., et al. 2013. Eur J Pharmacol. 715: 296-303. PMID: 23707352
- Effect of molsidomine on thrombus formation in stenosed coronary arteries of dogs and pigs. | Just, M. and Martorana, PA. 1989. J Cardiovasc Pharmacol. 14 Suppl 11: S129-36. PMID: 2484691
- Protective and therapeutic effects of molsidomine on radiation induced neural injury in rats. | Durak, MA., et al. 2017. Biotech Histochem. 92: 68-77. PMID: 28166419
- Mode of action of nitrates with regard to vasodilatation and tolerance. | Kukovetz, WR. and Holzmann, S. 1986. Z Kardiol. 75 Suppl 3: 8-11. PMID: 2879392
- Mechanism of vasodilation by molsidomine. | Kukovetz, WR. and Holzmann, S. 1985. Am Heart J. 109: 637-40. PMID: 2983523
- Molsidomine: alternative approaches to treat myocardial ischemia. | Nitz, RE. and Fiedler, VB. 1987. Pharmacotherapy. 7: 28-37. PMID: 3554158
- In-vivo and in-vitro correlation for delayed-release behaviour of a molsidomine/O-carboxymethyl-O-ethyl-beta-cyclodextrin complex in gastric acidity-controlled dogs. | Horikawa, T., et al. 1995. J Pharm Pharmacol. 47: 124-7. PMID: 7602466
- Long-term administration of L-arginine, L-NAME, and the exogenous NO donor molsidomine modulates urinary nitrate and cGMP excretion in rats. | Böger, RH., et al. 1994. Cardiovasc Res. 28: 494-9. PMID: 8181036
- Effect of molsidomine and free radical scavengers on the pulmonary thromboembolism in mice. | Dikshit, M., et al. 1993. Thromb Res. 70: 317-27. PMID: 8332961
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Molsidomine, 50 mg | sc-200337 | 50 mg | $20.00 | |||
Molsidomine, 250 mg | sc-200337A | 250 mg | $33.00 |