Molecular structure of MK 0524
MK 0524 (CAS 571170-77-9)
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Alternate Names:
Laropiprant
Application:
MK 0524 is a potent, selective DP1 receptor antagonist
CAS Number:
571170-77-9
Molecular Weight:
435.90
Molecular Formula:
C21H19ClFNO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
MK 0524 is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 μM for the DP1 and DP2 receptors, respectively. It inhibits PGD2-induced accumulation of cAMP in both washed platelets and platelet-rich plasma with IC50 values of 0.09 and 4.0 nM, respectively. In a sheep model of allergic rhinitis, 0.1 mg/kg MK 0524 completely blocked PGD2-induced nasal congestion. At a dose of 4 mg/kg, MK 0524 suppressed a nicotinic acid-induced vasodilatory response by 80% in a murine model of flushing, an undesirable side-effect of niacin treatment for dyslipidemia.
Inhibitor of:
DP, and Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MK 0524, 1 mg | sc-396720 | 1 mg | $146.00 | |||
MK 0524, 5 mg | sc-396720A | 5 mg | $465.00 |