MJ33 (CAS 1135306-36-3)
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MJ33 is a chemical compound utilized in biochemical research, particularly for its role as an inhibitor of phospholipase A2 (PLA2), an enzyme critical in the hydrolysis of phospholipids. This compound helps researchers understand the complex mechanisms of enzyme regulation and lipid metabolism. By studying MJ33′s inhibitory effects on PLA2, scientists can explore the enzyme′s involvement in cellular processes and its broader implications in lipid signaling pathways. The use of MJ33 in experimental applications contributes to the mapping of metabolic pathways that are essential for cell membrane integrity and function. Furthermore, the compound is instrumental in the study of signal transduction mechanisms, where alterations in lipid mediators play a significant role.
MJ33 (CAS 1135306-36-3) References
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- A competitive inhibitor of phospholipase A2 decreases surfactant phosphatidylcholine degradation by the rat lung. | Fisher, AB., et al. 1992. Biochem J. 288 (Pt 2): 407-11. PMID: 1463444
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- Protection against LPS-induced acute lung injury by a mechanism-based inhibitor of NADPH oxidase (type 2). | Lee, I., et al. 2014. Am J Physiol Lung Cell Mol Physiol. 306: L635-44. PMID: 24487388
- Inhibition of the phospholipase A2 activity of peroxiredoxin 6 prevents lung damage with exposure to hyperoxia. | Benipal, B., et al. 2015. Redox Biol. 4: 321-7. PMID: 25637741
- Peroxiredoxins prevent oxidative stress during human sperm capacitation. | Lee, D., et al. 2017. Mol Hum Reprod. 23: 106-115. PMID: 28025393
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- Acidic Calcium-Independent Phospholipase A2 Regulates Eosinophil-Mediated Pathology during Filarial Manifestation of Tropical Pulmonary Eosinophilia. | Sharma, P., et al. 2021. J Immunol. 206: 722-736. PMID: 33441441
- Porcine Picornavirus 3C Protease Degrades PRDX6 to Impair PRDX6-mediated Antiviral Function. | Wang, C., et al. 2021. Virol Sin. 36: 948-957. PMID: 33721217
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- Crystal structure of the complex of bovine pancreatic phospholipase A2 with the inhibitor 1-hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol, | Sekar, K., et al. 1997. Biochemistry. 36: 14186-91. PMID: 9369492
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MJ33, 5 mg | sc-221947 | 5 mg | $256.00 |