Molecular structure of MitoPBN, CAS Number: 652968-37-1
MitoPBN (CAS 652968-37-1)
Alternate Names:
Phosphonium,[4-[4-[[(1,1-dimethylethyl)oxidoimino]methyl]phenoxy]butyl]triphenyl-,bromide
Application:
MitoPBN is a nitrone antioxidant derived from IBTP
CAS Number:
652968-37-1
Purity:
≥95%
Molecular Weight:
590.5
Molecular Formula:
C33H37BrNO2P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
This is a nitrone antioxidant derived from IBTP, which blocks superoxide-induced lipid peroxidation in rat liver mitochondrial preparations without disrupting normal mitochondrial functions when used at concentrations that are below 25 µM. It selectively and rapidly traps carbon-centered secondary radicals, but is unreactive towards superoxide anion (O2-•) or alkylperoxide radicals (ROO•).
MitoPBN (CAS 652968-37-1) References
- Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone. | Murphy, MP., et al. 2003. J Biol Chem. 278: 48534-45. PMID: 12972420
- Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences. | Smith, RA., et al. 2003. Biochem Soc Trans. 31: 1295-9. PMID: 14641046
- Mitochondrial oxidative damage in aging and Alzheimer's disease: implications for mitochondrially targeted antioxidant therapeutics. | Reddy, PH. 2006. J Biomed Biotechnol. 2006: 31372. PMID: 17047303
- Mitochondria-targeted antioxidants do not prevent tumour necrosis factor-induced necrosis of L929 cells. | Jarvis, RM., et al. 2007. Free Radic Res. 41: 1041-6. PMID: 17729122
- Small molecules as therapeutic drugs for Alzheimer's disease. | Oliver, DMA. and Reddy, PH. 2019. Mol Cell Neurosci. 96: 47-62. PMID: 30877034
- Liver-targeted Nano-MitoPBN normalizes glucose metabolism by improving mitochondrial redox balance. | Wu, M., et al. 2019. Biomaterials. 222: 119457. PMID: 31476661
- Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress. | Yamada, Y., et al. 2020. Biomolecules. 10: PMID: 31948035
- Compartmentally scavenging hepatic oxidants through AMPK/SIRT3-PGC1α axis improves mitochondrial biogenesis and glucose catabolism. | Wu, M., et al. 2021. Free Radic Biol Med. 168: 117-128. PMID: 33794310
- Targeting Oxidative Stress Mechanisms to Treat Alzheimer's and Parkinson's Disease: A Critical Review. | Aborode, AT., et al. 2022. Oxid Med Cell Longev. 2022: 7934442. PMID: 35958022
- Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders. | Almikhlafi, MA., et al. 2023. Curr Neuropharmacol. 21: 1165-1183. PMID: 36043795
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MitoPBN, 10 mg | sc-221946 | 10 mg | $366.00 |