MGA Antibody (MGA6A4H5): sc-81105

MGA Antibody (MGA6A4H5) is a mouse monoclonal IgG1 antibody that detects MGA protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-MGA antibody (MGA6A4H5) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. MGA protein, also known as MAX gene associated or MAD5, plays a crucial role in regulating cell proliferation and differentiation through interactions with other transcription factors. Specifically, MGA is a member of the Mad family and can form heterodimers with proteins such as Max, which is essential for Myc function. These dimers bind to the E-box sequence CACGTG, influencing critical cellular processes like growth, proliferation, and apoptosis. Notably, MGA possesses a unique Myc-like basic helix-loop-helix (bHLH) motif and a T-box DNA-binding domain, allowing MGA to regulate transcription of both MAX-network and T-box target genes. This dual functionality enables MGA to act as both a transcriptional repressor and activator, highlighting MGA′s significance in cellular signaling pathways. Furthermore, MGA is widely expressed and is considered a potential antagonist of Myc oncoproteins, making MGA a valuable target for research in cancer biology and therapeutic development.

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MGA Antibody (MGA6A4H5) References:

1. Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif.  |  Hurlin, PJ., et al. 1999. EMBO J. 18: 7019-28. PMID: 10601024
2. The Myc/Max/Mad network and the transcriptional control of cell behavior.  |  Grandori, C., et al. 2000. Annu Rev Cell Dev Biol. 16: 653-99. PMID: 11031250
3. The conserved Mynd domain of BS69 binds cellular and oncoviral proteins through a common PXLXP motif.  |  Ansieau, S. and Leutz, A. 2002. J Biol Chem. 277: 4906-10. PMID: 11733528
4. A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.  |  Ogawa, H., et al. 2002. Science. 296: 1132-6. PMID: 12004135
5. The evolutionary relationships of zebrafish genes tbx6, tbx16/spadetail and mga.  |  Lardelli, M. 2003. Dev Genes Evol. 213: 519-22. PMID: 12908107
6. The Mad side of the Max network: antagonizing the function of Myc and more.  |  Rottmann, S. and Lüscher, B. 2006. Curr Top Microbiol Immunol. 302: 63-122. PMID: 16620026
7. The MAX-interacting transcription factor network.  |  Hurlin, PJ. and Huang, J. 2006. Semin Cancer Biol. 16: 265-74. PMID: 16908182
8. Mga safeguards embryonic stem cells from acquiring extraembryonic endoderm fates.  |  Qin, J., et al. 2021. Sci Adv. 7: PMID: 33523934
9. Sarcoma with MGA::NUTM1 fusion: a report of three cases and literature review.  |  Wangsiricharoen, S., et al. 2023. Histopathology. 83: 712-721. PMID: 37442637
10. MGA deletion leads to Richter's transformation by modulating mitochondrial OXPHOS.  |  Iyer, P., et al. 2024. Sci Transl Med. 16: eadg7915. PMID: 39083585
11. MGA loss-of-function variants cause premature ovarian insufficiency.  |  Tang, S., et al. 2024. J Clin Invest. 134: PMID: 39545409
12. MGA-related syndrome: A proposed novel disorder.  |  McGivern, B., et al. 2025. HGG Adv. 6: 100387. PMID: 39600096

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MGA Antibody (MGA6A4H5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-MGA Antibody (MGA6A4H5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MGA Antibody (MGA6A4H5) Specifications

Alternate Product Name: MGA

Product Clone Name: MGA6A4H5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: MGA

Epitope Species: human

Product Reactivity/Detection: MGA

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for MGA Antibody (MGA6A4H5): N/A