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Methyl 4-chloro-1H-pyrrole-2-carboxylate (CAS 1194-96-3)

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CAS Number:
1194-96-3
Molecular Weight:
159.57
Molecular Formula:
C6H6ClNO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Methyl 4-chloro-1H-pyrrole-2-carboxylate is a compound used in organic chemistry research primarily as an intermediate for the synthesis of more complex organic molecules. Its pyrrole ring, a heterocyclic aromatic organic compound, makes it a key substrate in heterocyclic chemistry. The chlorine atom on the pyrrole ring is a reactive site that can undergo various substitution reactions, enabling the introduction of different functional groups. This reactivity is exploited in the synthesis of pharmaceuticals and agrochemicals, where the pyrrole moiety is often found in biologically active compounds. The methyl ester group of methyl 4-chloro-1H-pyrrole-2-carboxylate provides an additional point of functionalization and can be readily transformed into other functional groups through hydrolysis or transesterification reactions. In materials science, the electronic properties of pyrrole derivatives are of interest for the development of conductive polymers and other advanced materials.


Methyl 4-chloro-1H-pyrrole-2-carboxylate (CAS 1194-96-3) References

  1. Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors.  |  Xiang, HY., et al. 2021. Bioorg Med Chem Lett. 31: 127710. PMID: 33246105
  2. Tris(4-bromophenyl)aminium Hexachloroantimonate as a 'Waste-Utilized'-Type Initiator-Promoted C-H Chlorination via C-H Activation Relay: Synthesis of Chlorinated Pyrroles.  |  Ding, H., et al. 2022. J Org Chem. 87: 15139-15151. PMID: 36398528
  3. Methyl 4-chloro-3, 5-di-p-tolyl-1H-pyrrole-2-carboxylate dichloromethane hemisolvate.  |  Gardiner, M. G., Jones, R. C., Ng, S., & Smith, J. A. (2007). Acta Crystallographica Section E: Structure Reports Online,. 63(1),: o197-o199.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Methyl 4-chloro-1H-pyrrole-2-carboxylate, 500 mg

sc-328709
500 mg
$507.00

Methyl 4-chloro-1H-pyrrole-2-carboxylate, 1 g

sc-328709A
1 g
$688.00