Molecular structure of Methoxamine hydrochloride, CAS Number: 61-16-5
Methoxamine hydrochloride (CAS 61-16-5)
See product citations (3)
Alternate Names:
vasoxine hydrochloride
Application:
Methoxamine hydrochloride is An agonist to α-1-adrenoceptors
CAS Number:
61-16-5
Molecular Weight:
247.72
Molecular Formula:
C11H17NO3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Methoxamine hydrochloride is an agonist to alpha-1-adrenoceptors that causes prolonged peripheral vasoconstriction. This results in an elevation of blood pressure and a reduction in blood flow. Researchers may use this compound to explore its effects on various biological systems, including vascular function, smooth muscle contraction, and sympathetic nervous system activity.
Methoxamine hydrochloride (CAS 61-16-5) References
- Comparison of the effects of venlafaxine, desipramine, and paroxetine on noradrenaline- and methoxamine-evoked constriction of the dorsal hand vein. | Abdelmawla, AH., et al. 1999. Br J Clin Pharmacol. 48: 345-54. PMID: 10510145
- Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro. | Bischoff, A., et al. 2000. Br J Pharmacol. 130: 1871-7. PMID: 10952677
- The effect of methoxamine hydrochloride (vasoxyl) on cardiac rhythm. | LAHTI, RE., et al. 1955. J Pharmacol Exp Ther. 115: 268-74. PMID: 13272176
- Noradrenergic stimulation of BDNF synthesis in astrocytes: mediation via alpha1- and beta1/beta2-adrenergic receptors. | Juric, DM., et al. 2008. Neurochem Int. 52: 297-306. PMID: 17681645
- Cardiovascular effects of Ekebergia capensis Sparrm (Meliaceae) ethanolic leaf extract in experimental animal paradigms. | Kamadyaapa, DR., et al. 2009. Cardiovasc J Afr. 20: 162-7, 169. PMID: 19575078
- Investigations into the specific effects of rosemary oil at the receptor level. | Sagorchev, P., et al. 2010. Phytomedicine. 17: 693-7. PMID: 20034774
- Assessment of proarrhythmic activity of chloroquine in in vivo and ex vivo rabbit models. | Khobragade, SB., et al. 2013. J Pharmacol Pharmacother. 4: 116-24. PMID: 23759957
- A randomised, controlled, crossover study to investigate the safety and response of 1R,2S-methoxamine hydrochloride (NRL001) on anal function in healthy volunteers. | Simpson, JA., et al. 2014. Colorectal Dis. 16 Suppl 1: 5-15. PMID: 24499492
- A randomised, controlled, crossover study to investigate the pharmacodynamics, pharmacokinetics and safety of 1R,2S-methoxamine hydrochloride (NRL001) in healthy elderly subjects. | Bell, D., et al. 2014. Colorectal Dis. 16 Suppl 1: 27-35. PMID: 24499494
- Neurogenic hyperacute ascites in mice. | Nelson, DP., et al. 1986. Clin Sci (Lond). 71: 327-30. PMID: 2875822
- Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells. | Kotaka, M., et al. 2017. Sci Rep. 7: 16734. PMID: 29196668
- Metabolomics and microbiomes for discovering biomarkers of antituberculosis drugs-induced hepatotoxicity. | Wu, S., et al. 2022. Arch Biochem Biophys. 716: 109118. PMID: 34999018
- TRPA1, but not TRPV1, is involved in the increase of the non-adrenergic non-cholinergic outflow induced by hydrogen sulfide in pithed rats. | Huerta de la Cruz, S., et al. 2022. Peptides. 157: 170861. PMID: 35973467
- Comparison of the effects of methoxamine with those of noradrenaline and phenylephrine on single cerebral cortical neurones. | Bradshaw, CM., et al. 1981. Br J Pharmacol. 73: 47-54. PMID: 6269683
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Methoxamine hydrochloride, 500 mg | sc-263468 | 500 mg | $200.00 | |||
Methoxamine hydrochloride, 1 g | sc-263468A | 1 g | $352.00 |