Molecular structure of Mestranol, CAS Number: 72-33-3
Mestranol (CAS 72-33-3)
Alternate Names:
Menophase; Ovastol; Devocin
Application:
Mestranol is an orally active estrogenic steroid
CAS Number:
72-33-3
Purity:
≥99%
Molecular Weight:
310.43
Molecular Formula:
C21H26O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Mestranol is the 3-methyl ether of ethinylestradiol. It is a biologically inactive prodrug of ethinylestradiol to which it is demethylated in the liver with a conversion efficiency of 70% (50 mug of mestranol is pharmacokinetically bioequivalent to 35 mug of ethinylestradiol). Mestranol is a synthetic steroid hormone derived from 19-nortestosterone, a natural androgenic hormone. When mestranol is administered, it undergoes rapid liver metabolism, transforming into ethinyl estradiol.
Mestranol (CAS 72-33-3) References
- Microbial transformation of mestranol by Cunninghamella elegans. | Choudhary, MI., et al. 2005. Chem Pharm Bull (Tokyo). 53: 1011-3. PMID: 16079537
- Improved synthesis of mestranol and ethinyl estradiol (EE) related degradation products as authentic references. | Li, H., et al. 2008. Steroids. 73: 488-94. PMID: 18255111
- Design of a Mestranol 2-N-Piperazino-Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF-7 Breast Cancer Models. | Perreault, M., et al. 2017. ChemMedChem. 12: 177-182. PMID: 28060448
- Parallel Solid-Phase Synthesis using a New Diethylsilylacetylenic Linker and Leading to Mestranol Derivatives with Potent Antiproliferative Activities on Multiple Cancer Cell Lines. | Dutour, R., et al. 2018. Anticancer Agents Med Chem. 18: 1469-1481. PMID: 29521249
- Mestranol: the assignment of its 1H and 13C NMR spectra by means of two-dimensional NMR spectroscopy, and its photochemical decomposition. | Sedee, AG., et al. 1985. Steroids. 45: 101-18. PMID: 3003971
- The effect of mestranol and lynoestrenol on ovarian histamine in the rat. | Abdel-Aziz, A., et al. 1974. J Reprod Fertil. 40: 459-61. PMID: 4139257
- The fate of mestranol (17 -ethynylestradiol-3-methyl ether) in the isolated perfused rat liver. | Bolt, HM. and Remmer, H. 1973. Horm Metab Res. 5: 101-5. PMID: 4350573
- Cervical mucorrhea and spinnbarkeit in patients taking norethindrone plus mestranol (Norinyl 1-mg.). | Cohen, MR. 1968. Fertil Steril. 19: 405-10. PMID: 4869631
- Interaction of mestranol with taurocholate uptake by isolated rat hepatocytes. | Salhab, AS. and Dujovne, CA. 1979. Res Commun Chem Pathol Pharmacol. 26: 297-307. PMID: 523772
- [Effect of the prolonged treatment with norethynodrel and mestranol on the growth of young rats and on the incidence of caries in their dentition]. | Frumento, F., et al. 1968. Riv Ital Stomatol. 23: 1410-21. PMID: 5248455
- Failure of mestranol alone or with norethynodrel to prepare for the generalized Shwartzman reaction in rats. | Phillips, LL., et al. 1970. Am J Obstet Gynecol. 107: 210-6. PMID: 5462439
- Long-term study of oral contraception with norethindrone 2 mg. and mestranol 0.1 mg. | Hutcherson, WP., et al. 1966. Fertil Steril. 17: 59-67. PMID: 5901012
- Influence of 3-methylether of ethinylestradiol (Mestranol) on oviductal egg transport in rats. | Oettel, M., et al. 1978. Endokrinologie. 71: 266-76. PMID: 688977
- Simple high-performance liquid chromatographic assay for norethindrone--mestranol in combination tablets. | Sundaresan, GM., et al. 1981. J Pharm Sci. 70: 702-4. PMID: 7252827
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mestranol, 10 mg | sc-211802 | 10 mg | $233.00 |