Mepyramine maleate is a histamine H1 receptor antagonist and binds with high affinity to G(q/11) protein. Mepyramine maleate is found to be a potent inhibitor of CYP2D6 (P450 2D forms) in hepatocytes, and PAF-induced platelet aggregation. Mepyramine maleate is commonly utilized as a radioligand ([3H]Mepyramine) binding assay for the H1 receptor. This product has been recently discovered to exhibit blocking ability of KCNQ/M channels which is potentially related to an adverse effect seen in excess intake of antihistamines.
1. Liu, Y.Q., et al. 1992. Biochem. Biophys. Res. Commun. 189: 378-384. PMID: 1449491 2. Zeng, S. and Guo, Z.G. 1997. Zhongguo Yao Li Xue Bao. 18: 155-158. PMID: 10072970 3. Vleeming, W., et al. 2000. Br. J. Pharmacol. 129: 1801-1807. PMID: 10780989 4. Fitzsimons, C.P., et al. 2004. J. Biol. Chem. 279: 34431-34439. PMID: 15192105 5. Liu, B., et al. 2008. Neuropharmacology. 54: 629-639. PMID: 18222495
Soluble in water (100 mg/ml), methanol, Phosphate buffered saline (100 mM), alcohol (1: 2.5 - 3.0), and chloroform (1: 2).
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
LiuLiu, B. et al. (PubMed 18222495) reported that the antihistamine Mepyramine maleate directly inhibits KCNQ/M channel and depolarizes rat superior cervical ganglion neurons. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
You may not log in without verifying your email address. Please check your email (including your spam email) for the Welcome message that was sent.
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.
Already have an account?
Please check your email (including your spam email) for a Welcome message, and verify your email address to continue.