Mel-18 Antibody (9HL1): sc-130415
- Mel-18 Antibody (9HL1) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant Mel-18 of human origin
- recommended for detection of Mel-18 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Mel-18 Antibody (9HL1). This work is in progress.
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SEE ALSO...
Mel-18 Antibody (9HL1) is a mouse monoclonal IgG2a antibody that detects Mel-18 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Mel-18, a member of the Polycomb group gene family, plays a crucial role in the regulation of gene expression and is essential for proper embryonic development. Mel-18 (9HL1) antibody targets a protein primarily located in the nucleus, where Mel-18 functions as a transcriptional repressor, binding to DNA via its RING-finger motif and interacting with enhancer elements of various target genes, including Bcl-2 and c-Myc. The importance of Mel-18′s nuclear localization lies in its ability to modulate chromatin structure and influence gene expression patterns that are vital for cellular processes such as proliferation and differentiation. Notably, Mel-18 acts as a tumor suppressor by negatively regulating cell cycle progression, thereby preventing uncontrolled cell growth. In contrast, its homolog Bmi-1 has been identified as an oncogene, highlighting the delicate balance between these proteins in cellular regulation and their implications in cancer biology. Anti-Mel-18 antibody (9HL1) is an invaluable tool for researchers studying the intricate roles of Polycomb group proteins in development and disease.
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Mel-18 Antibody (9HL1) References:
- Low expression of Mel-18 predicts poor prognosis in patients with breast cancer. | Guo, BH., et al. 2010. Ann Oncol. 21: 2361-2369. PMID: 20444850
- Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells. | Jung, JH., et al. 2010. Biochem Biophys Res Commun. 400: 523-30. PMID: 20801102
- MEL-18 loss mediates estrogen receptor-α downregulation and hormone independence. | Lee, JY., et al. 2015. J Clin Invest. 125: 1801-14. PMID: 25822021
- MEL-18, a tumor suppressor for aggressive breast cancer. | Lee, JY. and Kong, G. 2015. Oncotarget. 6: 15710-1. PMID: 26158291
- Mel-18 negatively regulates stem cell-like properties through downregulation of miR-21 in gastric cancer. | Wang, XF., et al. 2016. Oncotarget. 7: 63352-63361. PMID: 27542229
- Prognostic Significance of BMI-1 But Not MEL-18 Expression in Pulmonary Squamous Cell Carcinoma. | Abe, S., et al. 2017. Anticancer Res. 37: 1923-1929. PMID: 28373461
- Expression and Clinicopathological Significance of Mel-18 and Bmi-1 in Esophageal Squamous Cell Carcinoma. | Ji, H., et al. 2017. Technol Cancer Res Treat. 16: 828-834. PMID: 28425347
- BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3. | Liu, X., et al. 2017. Gastroenterology. 153: 1607-1620. PMID: 28780076
- Role of MEL-18 Amplification in Anti-HER2 Therapy of Breast Cancer. | Lee, JY., et al. 2019. J Natl Cancer Inst. 111: 609-619. PMID: 30265336
- AKT-mediated regulation of chromatin ubiquitylation and tumorigenesis through Mel18 phosphorylation. | Mai, J., et al. 2021. Oncogene. 40: 2422-2436. PMID: 33664452
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mel-18 Antibody (9HL1) | sc-130415 | 100 µg/ml | $339.00 |