Molecular structure of MDL-72222, CAS Number: 40796-97-2
MDL-72222 (CAS 40796-97-2)
Alternate Names:
Bemesetron
Application:
MDL-72222 is a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors
CAS Number:
40796-97-2
Purity:
99%
Molecular Weight:
314.2
Molecular Formula:
C15H17Cl2NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MDL-72222 is a potent and highly selective antagonist at certain excitatory 5-hydroxytryptamine receptors on mammalian peripheral neurons. MDL-72222 is most often used to study the role of 5-HT3. Studies suggest the blockade of 5-HT3 receptors with MDL 72222 may ameliorate beta-amyloid protein-induced neurotoxicity by interfering with the increase of Ca2+, and then by inhibiting glutamate release, generation of reactive oxygen species and caspase-3 activity. Also used in the study of dopamine elevation in rats due to cocaine and amphetamine consumption.
MDL-72222 (CAS 40796-97-2) References
- 5-HT3 receptor antagonist MDL 72222 attenuates cocaine- and mazindol-, but not methylphenidate-induced neurochemical and behavioral effects in the rat. | Kankaanpää, A., et al. 2002. Psychopharmacology (Berl). 159: 341-50. PMID: 11823886
- Synthesis and regional rat brain distribution of [11C]MDL 72222: a 5HT3 receptor antagonist. | Barré, L., et al. 1992. Int J Rad Appl Instrum A. 43: 509-16. PMID: 1314791
- Attenuation of defensive analgesia in male mice by 5-HT3 receptor antagonists, ICS 205-930, MDL 72222, MDL 73147EF and MDL 72699. | Rodgers, RJ. and Shepherd, JK. 1992. Neuropharmacology. 31: 553-60. PMID: 1407395
- Blockade of 5-HT(3) receptor with MDL 72222 and Y 25130 reduces beta-amyloid protein (25--35)-induced neurotoxicity in cultured rat cortical neurons. | Ju Yeon Ban,. and Yeon Hee Seong,. 2005. Eur J Pharmacol. 520: 12-21. PMID: 16150439
- Dopamine neurotransmission is involved in the attenuating effects of 5-HT3 receptor antagonist MDL 72222 on acute methamphetamine-induced locomotor hyperactivity in mice. | Yoo, JH., et al. 2008. Synapse. 62: 8-13. PMID: 17948891
- MDL 72222, a selective 5-HT3 receptor antagonist, suppresses voluntary ethanol consumption in alcohol-preferring rats. | Fadda, F., et al. 1991. Alcohol Alcohol. 26: 107-10. PMID: 1878073
- MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors. | Fozard, JR. 1984. Naunyn Schmiedebergs Arch Pharmacol. 326: 36-44. PMID: 6472484
- Effects of the antagonists MDL 72222 and ketanserin on responses of cat carotid body chemoreceptors to 5-hydroxytryptamine. | Kirby, GC. and McQueen, DS. 1984. Br J Pharmacol. 83: 259-69. PMID: 6487893
- The 5-HT3 antagonist MDL-72222 exacerbates ethanol withdrawal seizures in mice. | Grant, KA., et al. 1994. Alcohol Clin Exp Res. 18: 410-4. PMID: 8048747
- Effects of the combined administration of the 5-HT3 antagonist MDL 72222 and ethanol on conditioning in the periadolescent and adult rat. | Rajachandran, L., et al. 1993. Pharmacol Biochem Behav. 46: 535-42. PMID: 8278430
- Positron emission tomographic studies of [11C]MDL 72222, a potential 5-HT3 receptor radioligand: distribution, kinetics and binding in the brain of the baboon. | Camsonne, R., et al. 1993. Neuropharmacology. 32: 65-71. PMID: 8429917
- 5-HT3 receptor antagonist MDL 72222 dose-dependently attenuates cocaine- and amphetamine-induced elevations of extracellular dopamine in the nucleus accumbens and the dorsal striatum. | Kankaanpää, A., et al. 1996. Pharmacol Toxicol. 78: 317-21. PMID: 8737967
- The 5-HT3 receptor antagonist, MDL 72222, dose-dependently potentiates morphine-induced immediate-early gene expression in the rat caudate putamen. | Frankel, PS., et al. 1998. Brain Res. 814: 186-93. PMID: 9838105
Inhibitor of:
ASMT, and SR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MDL-72222, 50 mg | sc-201132 | 50 mg | $185.00 |