MCP-2 Antibody (500-M69): sc-65363

MCP-2 Antibody (500-M69) is a mouse monoclonal IgG1 kappa light chain antibody that detects human MCP-2 by enzyme-linked immunosorbent assay (ELISA). Anti-MCP-2 antibody (500-M69) is available in a non-conjugated form, allowing for versatile applications in research. MCP-2, also known as CCL8, is a member of the C-C (or β) chemokine subfamily, characterized by a unique arrangement of conserved cysteine residues. MCP-2 plays a crucial role in the immune response by mediating the chemotaxis of various immune cells, particularly eosinophils and basophils, which are essential for combating allergic reactions and parasitic infections. MCP-2′s ability to attract these specific cell types highlights its importance in regulating inflammation and orchestrating the immune response. Additionally, MCP-2 is produced by various cells, including T lymphocytes, upon activation by cytokines such as interleukin-1, tumor necrosis factor-alpha, and interferon-gamma, underscoring MCP-2′s role in the dynamic interplay of immune signaling. Anti-MCP-2 antibody (500-M69) serves as an invaluable tool for researchers studying the mechanisms of immune regulation and inflammation.

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MCP-2 Antibody (500-M69) References:

1. IFN-gamma, but not IP-10, MCP-2 or IL-2 response to RD1 selected peptides associates to active tuberculosis.  |  Goletti, D., et al. 2010. J Infect. 61: 133-43. PMID: 20470822
2. Relationship between TLR4 and MCP2 expression levels and habitual abortion.  |  Li, XP., et al. 2016. Genet Mol Res. 15: PMID: 27173235
3. Serum levels of NLRC4 and MCP-2/CCL8 in patients with active Crohn's disease.  |  Irak, K., et al. 2021. PLoS One. 16: e0260034. PMID: 34788319
4. Monocyte chemotactic protein MCP-2 activates human basophil and eosinophil leukocytes similar to MCP-3.  |  Weber, M., et al. 1995. J Immunol. 154: 4166-72. PMID: 7535823
5. Monocyte chemotactic protein-1 (MCP-1), -2, and -3 are chemotactic for human T lymphocytes.  |  Taub, DD., et al. 1995. J Clin Invest. 95: 1370-6. PMID: 7883984
6. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails.  |  Charo, IF., et al. 1994. Proc Natl Acad Sci U S A. 91: 2752-6. PMID: 8146186
7. Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B.  |  Combadiere, C., et al. 1995. J Biol Chem. 270: 29671-5. PMID: 8530354
8. Human monocyte chemotactic proteins-2 and -3: structural and functional comparison with MCP-1.  |  Proost, P., et al. 1996. J Leukoc Biol. 59: 67-74. PMID: 8558070
9. Chemokines in seasonal allergic rhinitis.  |  Kuna, P., et al. 1996. J Allergy Clin Immunol. 97: 104-12. PMID: 8568122
10. Early signal transduction by the receptor to the chemokine monocyte chemotactic protein-1 in a murine T cell hybrid.  |  Dubois, PM., et al. 1996. J Immunol. 156: 1356-61. PMID: 8568234
11. Site-directed mutagenesis of monocyte chemoattractant protein-1 identifies two regions of the polypeptide essential for biological activity.  |  Beall, CJ., et al. 1996. Biochem J. 313 (Pt 2): 633-40. PMID: 8573103
12. Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2B as its functional receptors.  |  Gong, X., et al. 1997. J Biol Chem. 272: 11682-5. PMID: 9115216

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MCP-2 Antibody (500-M69) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-MCP-2 Antibody (500-M69) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MCP-2 Antibody (500-M69) Specifications

Alternate Product Name: CCL8 (MCP-2)

Product Clone Name: 500-M69

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: MCP-2

Epitope Species: human

Product Reactivity/Detection: MCP-2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for MCP-2 Antibody (500-M69): N/A

The preferred MCP-1-4/eotaxin antibody is MCP-1-4/eotaxin Antibody (B-2): sc-377082.