MARCH6 Antibody (1A5): sc-517051
- MARCH6 Antibody (1A5) is a mouse monoclonal IgG2b κ MARCH6 antibody provided at 100 µg/ml
- raised against amino acids 2-91 representing partial length MARCH6 of human origin
- recommended for detection of MARCH6 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MARCH6 Antibody (1A5). This work is in progress.
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MARCH6 Antibody (1A5) is a mouse monoclonal IgG2b kappa light chain antibody that detects MARCH6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-MARCH6 antibody (1A5) is available as the non-conjugated format. MARCH6, also known as RNF176 or TEB4, is a 910 amino acid multi-pass membrane protein that plays a crucial role in the ubiquitin-proteasome system, specifically functioning as an E3 ubiquitin-protein ligase. MARCH6 is primarily localized to the endoplasmic reticulum, where MARCH6 facilitates the transfer of ubiquitin from E2 ubiquitin-conjugating enzymes to target proteins, marking them for degradation. MARCH6′s importance lies in regulating protein turnover, which is essential for maintaining cellular homeostasis and responding to stress. Additionally, MARCH6 undergoes auto-ubiquitination, leading to proteasomal degradation, a process vital for controlling cellular levels and activity. A RING-CH-type zinc finger in MARCH6′s structure further underscores its role in mediating protein interactions and enzymatic activity.
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MARCH6 Antibody (1A5) References:
- A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation. | Swanson, R., et al. 2001. Genes Dev. 15: 2660-74. PMID: 11641273
- Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. | Bartee, E., et al. 2004. J Virol. 78: 1109-20. PMID: 14722266
- TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum. | Hassink, G., et al. 2005. Biochem J. 388: 647-55. PMID: 15673284
- Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI). | Kreft, SG., et al. 2006. J Biol Chem. 281: 4646-53. PMID: 16373356
- Ubiquitin, proteasomes, and the regulation of intracellular protein degradation. | Hochstrasser, M. 1995. Curr Opin Cell Biol. 7: 215-23. PMID: 7612274
- The ubiquitin-proteasome proteolytic pathway. | Ciechanover, A. 1994. Cell. 79: 13-21. PMID: 7923371
- The ubiquitin-mediated proteolytic pathway: mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins. | Ciechanover, A. and Schwartz, AL. 1994. FASEB J. 8: 182-91. PMID: 8119489
- A novel protein modification pathway related to the ubiquitin system. | Liakopoulos, D., et al. 1998. EMBO J. 17: 2208-14. PMID: 9545234
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MARCH6 Antibody (1A5) | sc-517051 | 100 µg/ml | $322.00 |