Date published: 2025-12-25

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Maleamic acid (CAS 557-24-4)

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Alternate Names:
Maleic Acid Monoamide
CAS Number:
557-24-4
Molecular Weight:
115.09
Molecular Formula:
C4H5NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Maleamic acid serves as an intermediate in the synthesis of a wide array of organic compounds, particularly in the generation of heterocyclic structures. This compound is instrumental in cyclization processes, where its ability to transform into imides expands the possibilities for creating diverse synthetic routes. It functions through engaging in condensation reactions with amines and amino acids. These reactions are necessary for the formation of amides and imides, thereby facilitating the exploration and development of novel organic molecules. The utility of maleamic acid in these reactions highlights its significant role in advancing the field of organic chemistry, where it contributes to the synthesis and study of complex molecular architectures.


Maleamic acid (CAS 557-24-4) References

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  2. N-(4-Meth-oxy-phen-yl)maleamic acid.  |  Gowda, BT., et al. 2010. Acta Crystallogr Sect E Struct Rep Online. 66: o1529-30. PMID: 21587779
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  4. N-(3-Nitro-phen-yl)maleamic acid.  |  Gowda, BT., et al. 2010. Acta Crystallogr Sect E Struct Rep Online. 66: o1671-2. PMID: 21587897
  5. Genomic analysis of Pseudomonas putida: genes in a genome island are crucial for nicotine degradation.  |  Tang, H., et al. 2012. Sci Rep. 2: 377. PMID: 22530095
  6. Prodrugs for masking bitter taste of antibacterial drugs--a computational approach.  |  Karaman, R. 2013. J Mol Model. 19: 2399-412. PMID: 23420399
  7. Polyampholyte/surfactant complexes at the water-air interface: a surface tension study.  |  Fechner, M. and Koetz, J. 2013. Langmuir. 29: 7600-6. PMID: 23721398
  8. Design, synthesis and in vitro kinetic study of tranexamic acid prodrugs for the treatment of bleeding conditions.  |  Karaman, R., et al. 2013. J Comput Aided Mol Des. 27: 615-35. PMID: 23881217
  9. Polycarbonate-Based Blends for Optical Non-linear Applications.  |  Stanculescu, F. and Stanculescu, A. 2016. Nanoscale Res Lett. 11: 87. PMID: 26873262
  10. Synthesis and pH-dependent hydrolysis profiles of mono- and dialkyl substituted maleamic acids.  |  Su, S., et al. 2017. Org Biomol Chem. 15: 8384-8392. PMID: 28948264
  11. Reversing the undesirable pH-profile of doxorubicin via activation of a di-substituted maleamic acid prodrug at tumor acidity.  |  Zhang, A., et al. 2017. Chem Commun (Camb). 53: 12826-12829. PMID: 29143021
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  14. 2-(4-N-maleimidophenyl)-6-methoxybenzofuran: a superior derivatizing agent for fluorimetric determination of aliphatic thiols by high-performance liquid chromatography.  |  Haj-Yehia, AI. and Benet, LZ. 1995. J Chromatogr B Biomed Appl. 666: 45-53. PMID: 7655620

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Maleamic acid, 25 g

sc-235555
25 g
$38.00