Maduramicin (CAS 79356-08-4)

Maduramicin, a polyether ionophore antibiotic, has garnered considerable interest in scientific research due to its unique mechanism of action and potential applications in various fields. Mechanistically, Maduramicin disrupts the function of cellular membranes by selectively binding to monovalent cations such as sodium and potassium. This ionophoric activity leads to the dysregulation of ion gradients across cell membranes, ultimately compromising cellular integrity and function. Maduramicin′s ability to disrupt cellular membranes makes it effective against a wide range of gram-positive bacteria, as well as some protozoa and fungi. In research, Maduramicin has been utilized as a tool to investigate cellular physiology, membrane biophysics, and ion transport mechanisms. Moreover, Maduramicin and its derivatives have been explored for their potential applications in agriculture, particularly as feed additives for improving animal growth performance and preventing coccidiosis in poultry. Additionally, Maduramicin has been studied for its potential use as an anticancer agent, with research focusing on its ability to induce apoptosis and inhibit tumor cell proliferation. Ongoing research continues to explore the diverse research applications of Maduramicin, offering promising avenues for understanding cellular biology.