Molecular structure of Lyso-PAF (C18), CAS Number: 74430-89-0
Lyso-PAF (C18) (CAS 74430-89-0)
Alternate Names:
1- O- octadecyl- sn- glyceryl- 3- phosphorylcholine
Application:
Lyso-PAF (C18) is a substrate for either PAF C-18 formation
CAS Number:
74430-89-0
Molecular Weight:
509.7
Molecular Formula:
C26H56NO6P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Lyso-PAF C-18 can be formed by either the action of PAF-AH on PAF C-181 or by the action of a CoA-independent transacylase on 1-O-octadecyl-2-acyl-glycerophosphocholine.2,3 Lyso PAF C-18 is a substrate for either PAF C-18 formation by the remodeling pathway4 or selective acylation with arachidonic acid by a CoA-independent transacylase.
Lyso-PAF (C18) (CAS 74430-89-0) References
- Conversion of 1-O-[3H]alkyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine to lyso platelet-activating factor by the CoA-independent transacylase in membrane fractions of human neutrophils. | Venable, ME., et al. 1991. J Biol Chem. 266: 18691-8. PMID: 1917993
- A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice. | Cheng, L., et al. 2009. Am J Physiol Endocrinol Metab. 297: E1276-82. PMID: 19773578
- A coenzyme A-independent transacylase is linked to the formation of platelet-activating factor (PAF) by generating the lyso-PAF intermediate in the remodeling pathway. | Uemura, Y., et al. 1991. J Biol Chem. 266: 8268-72. PMID: 2022643
- Platelet-activating factor. | Prescott, SM., et al. 1990. J Biol Chem. 265: 17381-4. PMID: 2170377
- Metabolite profiling of Breviolum minutum in response to acidification. | Jiang, J. and Lu, Y. 2019. Aquat Toxicol. 213: 105215. PMID: 31200330
- Fluoride exposure altered metabolomic profile in rat serum. | Yue, B., et al. 2020. Chemosphere. 258: 127387. PMID: 32947680
- Biochemical and metabolic responses of the deep-sea mussel Bathymodiolus platifrons to cadmium and copper exposure. | Zhou, L., et al. 2021. Aquat Toxicol. 236: 105845. PMID: 33984608
- Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake. | Guo, WL., et al. 2022. Curr Res Food Sci. 5: 515-530. PMID: 35281335
- Human plasma platelet-activating factor acetylhydrolase. Purification and properties. | Stafforini, DM., et al. 1987. J Biol Chem. 262: 4223-30. PMID: 3558407
- Effect of platelet activating factor on guinea-pig papillary muscle. | Camussi, G., et al. 1984. Experientia. 40: 697-9. PMID: 6086382
- Platelet-activating factor (PAF-acether), an activator of neutrophil functions. | Jouvin-Marche, E., et al. 1982. Agents Actions. 12: 716-20. PMID: 6299078
- Inhibition by ticlopidine of Paf-acether-induced in vitro aggregation of rabbit and human platelets. | Lalau Keraly, C., et al. 1984. Thromb Res. 34: 463-71. PMID: 6740569
- Biosynthesis of platelet-activating factor (PAF)acether). III. Formation of PAF-acether from synthetic substrates by stimulated murine macrophages. | Mencia-Huerta, JM., et al. 1982. J Immunol. 129: 804-8. PMID: 7086143
- Enzymatic studies of lyso platelet-activating factor acylation in human neutrophils and changes upon stimulation. | Venable, ME., et al. 1993. J Biol Chem. 268: 7965-75. PMID: 8463317
Inhibitor of:
PAFAH1B3.Activator of:
PAF-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lyso-PAF (C18), 1 mg | sc-203123 | 1 mg | $56.00 | |||
Lyso-PAF (C18), 25 mg | sc-203123A | 25 mg | $342.00 |