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Lynestrenol (CAS 52-76-6)

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Alternate Names:
19-Nor-4-pregnen-20-yn-17-beta-ol
CAS Number:
52-76-6
Molecular Weight:
284.44
Molecular Formula:
C20H28O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Lynestrenol is a synthetic progestogen that functions by binding to progesterone receptors in target tissues. This binding results in the modulation of gene transcription and subsequent changes in the endometrium, inhibiting ovulation and altering cervical mucus to prevent sperm penetration. Lynestrenol suppresses the secretion of gonadotropins, which are involved in the regulation of the menstrual cycle. At the molecular level, Lynestrenol′s mechanism of action involves the inhibition of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) release from the pituitary gland, ultimately leading to the prevention of follicular maturation and ovulation. This chemical′s ability to interact with progesterone receptors and modulate gene expression plays a key role in its functional activity within experimental contexts.


Lynestrenol (CAS 52-76-6) References

  1. Lynestrenol as a contraceptive preparation. Experience with a micro-dosage formulation.  |  Bloch, B. 1975. S Afr Med J. 49: 657-61. PMID: 1135704
  2. Effects of 0.5 mg. of lynestrenol daily on hypothalamic-pituitary-ovarian function.  |  Friedrich, E., et al. 1975. Am J Obstet Gynecol. 122: 642-9. PMID: 1146929
  3. In vivo induction of sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) by lynestrenol.  |  Siddique, YH. and Afzal, M. 2005. Indian J Exp Biol. 43: 291-3. PMID: 15816420
  4. Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone.  |  Korhonen, T., et al. 2008. J Steroid Biochem Mol Biol. 110: 56-66. PMID: 18356043
  5. Peroral lynestrenol and arterial disease in mentally retarded women. A case-control study based on autopsy findings.  |  Huovinen, K., et al. 1988. Acta Obstet Gynecol Scand. 67: 211-4. PMID: 3176939
  6. Plasma levels of norethindrone after single oral dose administration of norethindrone and lynestrenol.  |  Odlind, V., et al. 1979. Clin Endocrinol (Oxf). 10: 29-38. PMID: 436304
  7. Metabolism of lynestrenol: characterization of 3-hydroxylation using rabbit liver microsomes in vitro.  |  Yasuda, J., et al. 1984. J Steroid Biochem. 21: 777-80. PMID: 6527542
  8. Lynestrenol: a progesteronelike agent with immunostimulatory properties.  |  Wybran, J. 1980. Recent Results Cancer Res. 75: 180-4. PMID: 6972071
  9. Serum levels and pharmacokinetics of norethisterone after ingestion of lynestrenol: its relation to dose and stage of the menstrual cycle.  |  Kuhl, H., et al. 1982. Contraception. 26: 303-15. PMID: 7172676
  10. [Pharmacokinetics of norethindrone and lynestrenol studied by HPLC (author's transl)].  |  Yasuda, J., et al. 1981. Nihon Naibunpi Gakkai Zasshi. 57: 1159-66. PMID: 7319102
  11. Bioavailability of Lynestrenol.  |  Shrimanker, K., et al. 1980. Arzneimittelforschung. 30: 500-2. PMID: 7387763
  12. Effects of danazol and lynestrenol on serum lipoproteins in endometriosis.  |  Mälkönen, M., et al. 1980. Clin Pharmacol Ther. 28: 602-4. PMID: 7438678
  13. Lynestrenol, an amplifier of lymphocyte stimulation.  |  Wybran, J., et al. 1977. Biomedicine. 27: 16-9. PMID: 856311

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Lynestrenol, 5 mg

sc-489681
5 mg
$110.00