Molecular structure of LY 487379 hydrochloride, CAS Number: 353229-59-1
LY 487379 hydrochloride (CAS 353229-59-1)
Alternate Names:
2,2,2-Trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)ethanesulfonamide hydrochloride
Application:
LY 487379 hydrochloride is a positive allosteric modulator selective for mGluR-2
CAS Number:
353229-59-1
Molecular Weight:
488.91
Molecular Formula:
C21H19F3N2O4S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LY 487379 hydrochloride is a selective and potent inhibitor of the dopamine transporter (DAT). It functions by binding to the DAT and preventing the reuptake of dopamine from the synaptic cleft into the presynaptic neuron. This leads to an increase in dopamine levels in the synaptic cleft, ultimately enhancing dopaminergic neurotransmission. LY 487379 hydrochloride′s mechanism of action involves blocking the transport of dopamine back into the presynaptic neuron, thereby prolonging the action of dopamine at the postsynaptic receptor. This mechanism of action is for studying the role of dopamine in various physiological and pathological processes, as it allows to manipulate dopamine levels in the brain. LY 487379 hydrochloride′s ability to target the dopamine transporter may be useful for investigating the role of dopamine in reward, addiction, and motor control, among other functions. Its precise mechanism of action at the molecular level provides a means to modulate dopaminergic neurotransmission in experimental applications.
LY 487379 hydrochloride (CAS 353229-59-1) References
- The difference in effect of mGlu2/3 and mGlu5 receptor agonists on cognitive impairment induced by MK-801. | Vales, K., et al. 2010. Eur J Pharmacol. 639: 91-8. PMID: 20371226
- Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive-like responding in rats. | Nikiforuk, A., et al. 2010. J Pharmacol Exp Ther. 335: 665-73. PMID: 20739457
- Postsynaptic and presynaptic group II metabotropic glutamate receptor activation reduces neuronal excitability in rat midline paraventricular thalamic nucleus. | Hermes, ML. and Renaud, LP. 2011. J Pharmacol Exp Ther. 336: 840-9. PMID: 21139059
- Development of a selective and sensitive high-performance liquid chromatography-tandem mass spectrometry assay to support pharmacokinetic studies of LY-487,379 in rat and marmoset. | Gaudette, F., et al. 2018. J Chromatogr B Analyt Technol Biomed Life Sci. 1093-1094: 1-7. PMID: 29980099
- Synthesis and evaluation of 4-(2-fluoro-4-[11C]methoxyphenyl)-5-((2-methylpyridin-4-yl)methoxy)picolinamide for PET imaging of the metabotropic glutamate receptor 2 in the rat brain. | Kumata, K., et al. 2019. Bioorg Med Chem. 27: 483-491. PMID: 30611634
- Reversal of MK-801-Induced Disruptions in Social Interactions and Working Memory with Simultaneous Administration of LY487379 and VU152100 in Mice. | Cieślik, P., et al. 2019. Int J Mol Sci. 20: PMID: 31174329
- Interplay of Entorhinal Input and Local Inhibitory Network in the Hippocampus at the Origin of Slow Inhibition in Granule Cells. | Mircheva, Y., et al. 2019. J Neurosci. 39: 6399-6413. PMID: 31182636
- The highly selective mGlu2 receptor positive allosteric modulator LY-487,379 alleviates l-DOPA-induced dyskinesia in the 6-OHDA-lesioned rat model of Parkinson's disease. | Hamadjida, A., et al. 2020. Eur J Neurosci. 51: 2412-2422. PMID: 31944461
- Selective metabotropic glutamate receptor 2 positive allosteric modulation alleviates L-DOPA-induced psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset. | Sid-Otmane, L., et al. 2020. Eur J Pharmacol. 873: 172957. PMID: 32004527
- Combined mGlu2 orthosteric stimulation and positive allosteric modulation alleviates L-DOPA-induced psychosis-like behaviours and dyskinesia in the parkinsonian marmoset. | Nuara, SG., et al. 2020. J Neural Transm (Vienna). 127: 1023-1029. PMID: 32246204
- The mGlu2/3 antagonist LY-341,495 reverses the anti-dyskinetic and anti-psychotic effects of the mGlu2 activators LY-487,379 and LY-354,740 in the MPTP-lesioned marmoset. | Nuara, SG., et al. 2020. J Neural Transm (Vienna). 127: 1013-1021. PMID: 32333122
- Effect of the mGlu2 positive allosteric modulator CBiPES on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset. | Frouni, I., et al. 2021. J Neural Transm (Vienna). 128: 73-81. PMID: 33392826
- Additive effects of mGluR2 positive allosteric modulation, mGluR2 orthosteric stimulation and 5-HT2AR antagonism on dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset. | Nuara, SG., et al. 2021. Naunyn Schmiedebergs Arch Pharmacol. 394: 2381-2388. PMID: 34550406
- Anti-parkinsonian effect of the mGlu2 positive allosteric modulator LY-487,379 as monotherapy and adjunct to a low L-DOPA dose in the MPTP-lesioned marmoset. | Frouni, I., et al. 2023. Eur J Pharmacol. 939: 175429. PMID: 36502960
Inhibitor of:
GPR54.Activator of:
mGluR-2.Substrate of:
mGluR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY 487379 hydrochloride, 10 mg | sc-204065 | 10 mg | $145.00 | |||
LY 487379 hydrochloride, 50 mg | sc-204065A | 50 mg | $615.00 |