Molecular structure of LY 311727, CAS Number: 164083-84-5
LY 311727 (CAS 164083-84-5)
See product citations (3)
Alternate Names:
3-[3-(2-amino-2-oxoethyl)-1-benzyl-2-ethylindol-5-yl]oxypropylphosphonic acid
Application:
LY 311727 is a specific PLA2 inhibitor reported to attenuate VEGF-mediated platelet-activating factor synthesis
CAS Number:
164083-84-5
Purity:
≥97%
Molecular Weight:
430.43
Molecular Formula:
C22H27N2O5P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LY 311727 is a specific phospholipase A2 (sPLA2) inhibitor which has been reported to attenuate VEGF-mediated platelet-activating factor (PAF) synthesis in HUVEC and BAEC cells.
LY 311727 (CAS 164083-84-5) References
- Type IIA secretory phospholipase A2 up-regulates cyclooxygenase-2 and amplifies cytokine-mediated prostaglandin production in human rheumatoid synoviocytes. | Bidgood, MJ., et al. 2000. J Immunol. 165: 2790-7. PMID: 10946311
- VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A2. | Bernatchez, PN., et al. 2001. Br J Pharmacol. 134: 197-205. PMID: 11522612
- Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis. | Buitrago-Rey, R., et al. 2002. J Antimicrob Chemother. 49: 871-4. PMID: 12003987
- Arachidonic acid-activated Na+-dependent Mg2+ efflux in rat renal epithelial cells. | Ikari, A., et al. 2003. Biochim Biophys Acta. 1618: 1-7. PMID: 14643927
- Combined targeted Omic and Functional Assays Identify Phospholipases A₂ that Regulate Docking/Priming in Calcium-Triggered Exocytosis. | Dabral, D. and Coorssen, JR. 2019. Cells. 8: PMID: 30986994
- Group V Phospholipase A2 Mediates Endothelial Dysfunction and Acute Lung Injury Caused by Methicillin-Resistant Staphylococcus Aureus. | Htwe, YM., et al. 2021. Cells. 10: PMID: 34359901
- Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2. | Schevitz, RW., et al. 1995. Nat Struct Biol. 2: 458-65. PMID: 7664108
- Recombinant human secretory phospholipase A2 released thromboxane from guinea pig bronchoalveolar lavage cells: in vitro and ex vivo evaluation of a novel secretory phospholipase A2 inhibitor. | Fleisch, JH., et al. 1996. J Pharmacol Exp Ther. 278: 252-7. PMID: 8764358
- Transgenic model for the discovery of novel human secretory non-pancreatic phospholipase A2 inhibitors. | Fox, N., et al. 1996. Eur J Pharmacol. 308: 195-203. PMID: 8840132
- High-affinity aptamers selectively inhibit human nonpancreatic secretory phospholipase A2 (hnps-PLA2). | Bridonneau, P., et al. 1998. J Med Chem. 41: 778-86. PMID: 9526554
Inhibitor of:
group II sPLA2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY 311727, 10 mg | sc-358269 | 10 mg | $250.00 | |||
| US: Only available in the US | ||||||
LY 311727, 25 mg | sc-358269A | 25 mg | $660.00 | |||
| US: Only available in the US | ||||||
LY 311727, 100 mg | sc-358269B | 100 mg | $3200.00 | |||
| US: Only available in the US | ||||||