LTBP-4 Antibody (A-2): sc-393666

LTBP-4 Antibody (A-2) is a mouse monoclonal IgM antibody that detects LTBP-4 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-LTBP-4 antibody (A-2) is available as the non-conjugated form. LTBP-4, or latent TGFβ-binding protein 4, plays a crucial role in regulating transforming growth factor beta (TGFβ) signaling, which is essential for various cellular processes, including cell growth, differentiation, and tissue repair. LTBP-4 is primarily located in the extracellular matrix, serving as a structural component of connective tissue microfibrils and influencing TGFβ deposition and activation in tissues. This localization enables LTBP-4 to modulate TGFβ availability and activity in the local microenvironment, impacting processes such as wound healing and fibrosis. LTBP-4 exists in multiple isoforms due to alternative splicing, adding complexity to function and regulation. Human LTBP-4 gene is located at chromosomal position 19q13.1-19q13.2, with mRNA expressed in various tissues, including heart, aorta, uterus, and small intestine, highlighting importance in diverse physiological contexts.

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LTBP-4 Antibody (A-2) References:

1. Expression of isoforms and splice variants of the latent transforming growth factor beta binding protein (LTBP) in cultured human liver myofibroblasts.  |  Mangasser-Stephan, K., et al. 2001. Liver. 21: 105-13. PMID: 11318979
2. Novel non-TGF-beta-binding splice variant of LTBP-4 in human cells and tissues provides means to decrease TGF-beta deposition.  |  Koli, K., et al. 2001. J Cell Sci. 114: 2869-78. PMID: 11683420
3. Secretion of human latent TGF-beta-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-beta.  |  Penttinen, C., et al. 2002. J Cell Sci. 115: 3457-68. PMID: 12154076
4. Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer.  |  Sterner-Kock, A., et al. 2002. Genes Dev. 16: 2264-73. PMID: 12208849
5. Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.  |  Isogai, Z., et al. 2003. J Biol Chem. 278: 2750-7. PMID: 12429738
6. Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung.  |  Koli, K., et al. 2004. J Cell Biol. 167: 123-33. PMID: 15466481
7. Amino acid requirements for formation of the TGF-beta-latent TGF-beta binding protein complexes.  |  Chen, Y., et al. 2005. J Mol Biol. 345: 175-86. PMID: 15567420
8. Sequence and expression of a novel member (LTBP-4) of the family of latent transforming growth factor-beta binding proteins.  |  Giltay, R., et al. 1997. FEBS Lett. 411: 164-8. PMID: 9271198
9. Identification and characterization of a new latent transforming growth factor-beta-binding protein, LTBP-4.  |  Saharinen, J., et al. 1998. J Biol Chem. 273: 18459-69. PMID: 9660815

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LTBP-4 Antibody (A-2) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-LTBP-4 Antibody (A-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LTBP-4 Antibody (A-2) Specifications

Alternate Product Name: LTBP-4

Product Clone Name: A-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 1558-1581

Epitope Target: LTBP-4

Epitope Species: human

Product Reactivity/Detection: LTBP-4 long and short forms

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for LTBP-4 Antibody (A-2): P: Blocking Peptide