Molecular structure of Lovastatin-d3, CAS Number: 1002345-93-8
Lovastatin-d3 (CAS 1002345-93-8)
Alternate Names:
Lovalip-d3; Mevacor-d3
Application:
Lovastatin-d3 is a labelled Lovastatin
CAS Number:
1002345-93-8
Molecular Weight:
407.56
Molecular Formula:
C24H33D3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Lovastatin-d3 is a deuterated variant of lovastatin, a naturally occurring compound obtained from the fungus Aspergillus terreus. Lovastatin-d3 serves as useful in scientific research aimed at unraveling the mechanism of action of statins. Statins are known to inhibit the activity of the enzyme HMG-CoA reductase, which plays a vital role in cholesterol synthesis. Lovastatin-d3 enables the study of statin binding to HMG-CoA reductase, exploring the impact of deuterium substitution on the binding affinity. By effectively inhibiting HMG-CoA reductase, lovastatin-d3 curtails cholesterol production.
Lovastatin-d3 (CAS 1002345-93-8) References
- Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis. | Riedmaier, S., et al. 2011. Front Pharmacol. 2: 41. PMID: 21852972
- Development of MEPS-UHPLC-MS/MS multistatin methods for clinical analysis. | Vlčková, H., et al. 2016. Bioanalysis. 8: 333-49. PMID: 26858167
- Exploring the Occurrence and Temporal Variation of ToxCast Chemicals in Fine Particulate Matter Using Suspect Screening Strategy. | Lin, Y., et al. 2019. Environ Sci Technol. 53: 5687-5696. PMID: 31045341
- Stability indicating LC-MS/MS method for estimation of lovastatin in human plasma: application to a bioequivalence study | Arabinda Saha, Hemanth Jangala, Poonam Vats, Richa Thakur, Arshad Khuroo & Tausif Monif. 2015. Journal of Analytical Science and Technology. 6.
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HMGCR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lovastatin-d3, 1 mg | sc-280938 | 1 mg | $372.00 |