Molecular structure of Lomustine, CAS Number: 13010-47-4
Lomustine (CAS 13010-47-4)
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Alternate Names:
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea; Belustine; Cecenu; CeeNU; CINU
Application:
Lomustine is an alkylating antitumor nitrosourea agent
CAS Number:
13010-47-4
Purity:
≥97%
Molecular Weight:
233.70
Molecular Formula:
C9H16CIN3O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Lomustine is an alkylating nitrosourea compound that possesses antitumor activity similar to Carmustine (sc-204671) causing DNA interstrand cross-linking. The compound is also a documented inhibitor of glutathione reductase, DLD(lipoamide dehydrogenase) and trypanothione reductase. Lomustine is a highly lipid soluble compound thus enabling it to cross the blood brain barrier and rapidly disperse in tissue. In A2870 cells, Lomustine may act to induce p53 expression.
Lomustine (CAS 13010-47-4) References
- Mismatch repair and p53 independently affect sensitivity to N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea. | Aquilina, G., et al. 2000. Clin Cancer Res. 6: 671-80. PMID: 10690553
- Lomustine and prednisone as a first-line treatment for dogs with multicentric lymphoma: 17 cases (2004-2005). | Sauerbrey, ML., et al. 2007. J Am Vet Med Assoc. 230: 1866-9. PMID: 17571992
- Lomustine for treatment of mast cell tumors in cats: 38 cases (1999-2005). | Rassnick, KM., et al. 2008. J Am Vet Med Assoc. 232: 1200-5. PMID: 18412534
- Lomustine loaded chitosan nanoparticles: characterization and in-vitro cytotoxicity on human lung cancer cell line L132. | Mehrotra, A., et al. 2011. Chem Pharm Bull (Tokyo). 59: 315-20. PMID: 21372411
- Evaluation of lomustine as a rescue agent for cats with resistant lymphoma. | Dutelle, AL., et al. 2012. J Feline Med Surg. 14: 694-700. PMID: 22577051
- Spectroscopic analysis of the interaction of lomustine with calf thymus DNA. | Agarwal, S., et al. 2014. J Photochem Photobiol B. 130: 281-6. PMID: 24368412
- Spectrofluorimetric determination of the antineoplastic agent lomustine based on the sensitizing effect of β-cyclodextrin. | Fisli, H., et al. 2016. Luminescence. 31: 871-80. PMID: 26510489
- A comparative analysis of drug-induced DNA effects in a nitrogen mustard resistant cell line expressing sensitivity to nitrosoureas. | Dean, SW., et al. 1986. Biochem Pharmacol. 35: 1171-6. PMID: 2938589
- Inactivation of purified human O6-alkylguanine-DNA alkyltransferase by alkylating agents or alkylated DNA. | Brent, TP. 1986. Cancer Res. 46: 2320-3. PMID: 2938727
- DNA sequence selectivity of guanine-N7 alkylation by three antitumor chloroethylating agents. | Hartley, JA., et al. 1986. Cancer Res. 46: 1943-7. PMID: 3004713
- How did lomustine become standard of care in recurrent glioblastoma? | Weller, M. and Le Rhun, E. 2020. Cancer Treat Rev. 87: 102029. PMID: 32408220
- Treatment options for progression or recurrence of glioblastoma: a network meta-analysis. | McBain, C., et al. 2021. Cochrane Database Syst Rev. 5: CD013579. PMID: 34559423
- The Efficacy and Safety of Adjuvant Lomustine to Chemotherapy for Recurrent Glioblastoma: A Meta-analysis of Randomized Controlled Studies. | Fu, X., et al. Clin Neuropharmacol. 45: 162-167. PMID: 36383914
Inhibitor of:
DLD, Glutathione reductase, NG2, and PTN.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lomustine, 50 mg | sc-202697 | 50 mg | $99.00 |