Date published: 2025-12-29

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Lipoxidase (CAS 9029-60-1)

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Application:
Lipoxidase is catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure
CAS Number:
9029-60-1
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Lipoxidase is an enzyme that catalyzes the oxidation of polyunsaturated fatty acids to form hydroperoxides. It plays a role in lipid metabolism and is involved in the production of signaling molecules such as leukotrienes and lipoxins. The enzyme acts by abstracting a hydrogen atom from a polyunsaturated fatty acid, initiating a chain reaction that leads to the formation of lipid hydroperoxides. This process is important for the regulation of inflammation and immune responses. Lipoxidase is also involved in the biosynthesis of various bioactive compounds, contributing to the modulation of cellular signaling pathways. Its mechanism of action at the molecular level involves the specific oxidation of fatty acids, leading to the generation of lipid-derived signaling molecules.


Lipoxidase (CAS 9029-60-1) References

  1. Linoleic acid and trilinolein as substrates for soybean lipoxidase (s).  |  KOCH, RB., et al. 1958. Arch Biochem Biophys. 78: 165-79. PMID: 13595914
  2. Characterization of the ketodienes formed in the oxidation of linoleate by lipoxidase.  |  VIOQUE, E. and HOLMAN, RT. 1962. Arch Biochem Biophys. 99: 522-8. PMID: 13997422
  3. Radiomimetic action of lipoxidase.  |  PUIG MUSET, P., et al. 1959. Nature. 184(Suppl 19): 1506-7. PMID: 14435272
  4. Spectrophotometric Method for Determination of Lipoxidase Activity.  |  Surrey, K. 1964. Plant Physiol. 39: 65-70. PMID: 16655881
  5. Pentane from thermal decomposition of lipoxidase-derived products.  |  Evans, CD., et al. 1967. Lipids. 2: 432-4. PMID: 17805706
  6. Mechanism of lipoxidase reaction. I. Specificity of hydroperoxidation of linoleic acid.  |  Dolev, A., et al. 1967. Lipids. 2: 28-32. PMID: 17805717
  7. Two rare antioxidative prenylated terpenoids from loop-root Asiatic mangrove Rhizophora mucronata (Family Rhizophoraceae) and their activity against pro-inflammatory cyclooxygenases and lipoxidase.  |  Raola, VK. and Chakraborty, K. 2017. Nat Prod Res. 31: 418-427. PMID: 27125851
  8. Unprecedented antioxidative cyclic ether from the red seaweed Kappaphycus alvarezii with anti-cyclooxygenase and lipoxidase activities.  |  Makkar, F. and Chakraborty, K. 2017. Nat Prod Res. 31: 1131-1141. PMID: 27627183
  9. Development of a method to screen and isolate lipoxidase inhibitors from Radix Saposhnikoviae via ultrafiltration liquid chromatography combined with metablism in vitro.  |  Huang, Y., et al. 2020. Phytochem Anal. 31: 937-947. PMID: 32656897
  10. Screening and isolation of potential lipoxidase and superoxide dismutase inhibitors from Scutellaria baicalensis Georgi using high-speed countercurrent chromatography target-guided by ultrafiltration-liquid chromatography-mass spectrometry.  |  Xia, J., et al. 2021. J Sep Sci. 44: 1371-1382. PMID: 33433962
  11. Single-step screening and isolation of potential lipoxidase inhibitors from Trifolium repens by stepwise flow rate high-speed countercurrent chromatography and semipreparative high-performance liquid chromatography target-guided by ultrafiltration-LC-MS.  |  Wang, Y., et al. 2021. J Sep Sci. 44: 2875-2887. PMID: 34043286
  12. Tumor-killing nanoreactors fueled by tumor debris can enhance radiofrequency ablation therapy and boost antitumor immune responses.  |  Yang, Z., et al. 2021. Nat Commun. 12: 4299. PMID: 34262038
  13. Isolation of soybean lipoxidase by isoelectric focusing.  |  Catsimpoolas, N. 1969. Arch Biochem Biophys. 131: 185-90. PMID: 5813833

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Lipoxidase, 100 mg

sc-487285
100 mg
$132.00