Date published: 2025-12-19

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Lincomycin (U-10149A) (CAS 859-18-7)

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Alternate Names:
Lincomycin hydrochloride
Application:
Lincomycin (U-10149A) is a supressor of protein synthesis in bacteria
CAS Number:
859-18-7
Purity:
≥95%
Molecular Weight:
442.99
Molecular Formula:
C18H35ClN2O6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Lincomycin (U-10149A) is frequently used in research focused on bacterial protein synthesis, particularly in studies related to ribosome function and structure. It serves as a useful tool for investigating the mechanisms by which bacteria synthesize proteins and how this process can be disrupted. Research involving Lincomycin (U-10149A) often examines its binding interactions with the 50S ribosomal subunit, providing insights into the molecular dynamics of ribosomal inhibition. Moreover, Lincomycin (U-10149A) is utilized in studies aimed at understanding resistance mechanisms in bacteria, helping to elucidate how genetic and adaptive changes allow bacteria to circumvent such inhibition. Additionally, Lincomycin (U-10149A) plays a role in environmental microbiology research, where its effects on microbial communities can be assessed, particularly in soil and water ecosystems.


Lincomycin (U-10149A) (CAS 859-18-7) References

  1. Bacterial ribosomal subunit synthesis: a novel antibiotic target.  |  Champney, WS. 2001. Curr Drug Targets Infect Disord. 1: 19-36. PMID: 12455231
  2. Crystal and molecular structure and absolute configuration of lincomycin hydrochloride monohydrate.  |  Rajeswaran, M. and Srikrishnan, T. 2004. Carbohydr Res. 339: 2111-5. PMID: 15358090
  3. Lincosamides: chemical structure, biosynthesis, mechanism of action, resistance, and applications.  |  Spízek, J., et al. 2004. Adv Appl Microbiol. 56: 121-54. PMID: 15566978
  4. Study of the depletion of lincomycin residues in honey extracted from treated honeybee (Apis mellifera L.) colonies and the effect of the shook swarm procedure.  |  Adams, SJ., et al. 2009. Anal Chim Acta. 637: 315-20. PMID: 19286045
  5. A flow injection chemiluminescence method for the determination of lincomycin in serum using a diperiodato-cuprate (III)-luminol system.  |  Hu, Y., et al. 2011. Luminescence. 26: 313-8. PMID: 22021244
  6. Lincomycin resistance, a new type of maternally inherited mutation in Nicotiana plumbaginifolia.  |  Cséplő, A. and Maliga, P. 1982. Curr Genet. 6: 105-9. PMID: 24186475
  7. Study on the effects of microencapsulated Lactobacillus delbrueckii on the mouse intestinal flora.  |  Sun, Q., et al. 2015. J Microencapsul. 32: 669-76. PMID: 26471401
  8. Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids.  |  Czarniak, P., et al. 2016. Drug Des Devel Ther. 10: 1029-34. PMID: 27022242
  9. Effects of Schisandra chinensis polysaccharides on rats with antibiotic-associated diarrhea.  |  Qi, Y., et al. 2019. Int J Biol Macromol. 124: 627-634. PMID: 30500495
  10. Effects of lincomycin hydrochloride on the neurotoxicity of zebrafish.  |  Cheng, B., et al. 2020. Ecotoxicol Environ Saf. 201: 110725. PMID: 32474209
  11. Gut-Lung Dysbiosis Accompanied by Diabetes Mellitus Leads to Pulmonary Fibrotic Change through the NF-κB Signaling Pathway.  |  Wang, G., et al. 2021. Am J Pathol. 191: 838-856. PMID: 33705752
  12. Effects of Bacteroides-Based Microecologics against Antibiotic-Associated Diarrhea in Mice.  |  Guo, H., et al. 2021. Microorganisms. 9: PMID: 34946094
  13. Waste-converted nitrogen and fluorine co-doped porous carbon nanosheets for high performance supercapacitor with ionic liquid electrolyte.  |  Chen, C., et al. 2022. J Colloid Interface Sci. 616: 413-421. PMID: 35220188
  14. Panax quinquefolius Polysaccharides Ameliorate Antibiotic-Associated Diarrhoea Induced by Lincomycin Hydrochloride in Rats via the MAPK Signaling Pathways.  |  Ren, DD., et al. 2022. J Immunol Res. 2022: 4126273. PMID: 35345778
  15. A comparison of lincomycin hydrochloride and clindamycin hydrochloride in the treatment of superficial pyoderma in dogs.  |  Harvey, RG., et al. 1993. Vet Rec. 132: 351-3. PMID: 8488640

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Lincomycin (U-10149A), 1 g

sc-200105
1 g
$73.00

Lincomycin (U-10149A), 5 g

sc-200105A
5 g
$269.00

Lincomycin (U-10149A), 25 g

sc-200105B
25 g
$964.00