Liarozole hydrochloride, the hydrochloride salt preparation of Liarozole, is an imidazole-containing compound that suppresses cytochrome P-450-dependent metabolism of all-trans-retinoic-acid (ATRA). ATRA has been shown to be a metabolite of vitamin A. Studies report that some of the specific enzymes that are inhibited include CYP26s which are responsible for ATRA metabolism. Liarozole has also demonstrated the ability to inhibit aromatase, a key enzyme that is responsible for an important step in the biosynthesis of estrogens. Liarozole hydrochloride is an inhibitor of CYP19 and CYP26A1.
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