Molecular structure of Liarozole hydrochloride, CAS Number: 145858-50-0
Liarozole hydrochloride (CAS 145858-50-0)
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Alternate Names:
6-[(3-chlorophenyl)-imidazol-1-ylmethyl]-1H-benzimidazole hydrochloride
Application:
Liarozole hydrochloride is a Imidazole-containing compound that inhibits the cytochrome P450-dependent metabolism
CAS Number:
145858-50-0
Purity:
≥95%
Molecular Weight:
345.23
Molecular Formula:
C17H13ClN4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Liarozole hydrochloride, the hydrochloride salt preparation of Liarozole, is an imidazole-containing compound that suppresses cytochrome P-450-dependent metabolism of all-trans-retinoic-acid (ATRA). ATRA has been shown to be a metabolite of vitamin A. Studies report that some of the specific enzymes that are inhibited include CYP26s which are responsible for ATRA metabolism. Liarozole has also demonstrated the ability to inhibit aromatase, a key enzyme that is responsible for an important step in the biosynthesis of estrogens. Liarozole hydrochloride is an inhibitor of CYP19 and CYP26A1.
Liarozole hydrochloride (CAS 145858-50-0) References
- Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo. | Van Wauwe, J., et al. 1992. J Pharmacol Exp Ther. 261: 773-9. PMID: 1374473
- Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases. | Njar, VC., et al. 2006. Bioorg Med Chem. 14: 4323-40. PMID: 16530416
- Effects of liarozole fumarate (R85246) in combination with tamoxifen on N-methyl-N-nitrosourea (MNU)-induced mammary carcinoma and uterus in the rat model. | Goss, PE., et al. 2007. BMC Cancer. 7: 26. PMID: 17266767
- Expression of retinoid-regulated genes in lamellar ichthyosis vs. healthy control epidermis: changes after oral treatment with liarozole. | Pavez Loriè, E., et al. 2009. Acta Derm Venereol. 89: 12-20. PMID: 19197536
- Retinoic acid regulation by CYP26 in vertebrate lens regeneration. | Thomas, AG. and Henry, JJ. 2014. Dev Biol. 386: 291-301. PMID: 24384390
- Liarozole inhibits transforming growth factor-β3--mediated extracellular matrix formation in human three-dimensional leiomyoma cultures. | Levy, G., et al. 2014. Fertil Steril. 102: 272-281.e2. PMID: 24825427
- Trichostatin A reduces GnRH mRNA expression with a concomitant increase in retinaldehyde dehydrogenase in GnRH-producing neurons. | Kanasaki, H., et al. 2015. Mol Cell Endocrinol. 413: 113-9. PMID: 26116234
- PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis. | Pingitore, P., et al. 2016. Hum Mol Genet. 25: 5212-5222. PMID: 27742777
- Novel aromatase inhibitors selection using induced fit docking and extra precision methods: Potential clinical use in ER-alpha-positive breast cancer. | Kumavath, R., et al. 2016. Bioinformation. 12: 324-331. PMID: 28293075
- Liarozole fumarate inhibits the metabolism of 4-keto-all-trans-retinoic acid. | Van Wauwe, J., et al. 1994. Biochem Pharmacol. 47: 737-41. PMID: 8129749
- Aromatase inhibitors as potential cancer chemopreventives. | Kelloff, GJ., et al. 1998. Cancer Epidemiol Biomarkers Prev. 7: 65-78. PMID: 9456245
Inhibitor of:
17β-HSD3, CYP19, and CYP26A1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Liarozole hydrochloride, 10 mg | sc-204055 | 10 mg | $159.00 | |||
Liarozole hydrochloride, 50 mg | sc-204055A | 50 mg | $500.00 |