Liarozole hydrochloride CAS: 145858-50-0
MF: C17H13ClN4•HCl
MW: 345.23
An Imidazole-containing compound that inhibits the cytochrome P450-dependent metabolism.

Liarozole hydrochloride (CAS 145858-50-0)

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Alternate Names: 6-[(3-chlorophenyl)-imidazol-1-ylmethyl]-1H-benzimidazole hydrochloride
Application: Liarozole hydrochloride is a Imidazole-containing compound that inhibits the cytochrome P450-dependent metabolism
CAS Number: 145858-50-0
Purity: ≥95%
Molecular Weight: 345.23
Molecular Formula: C17H13ClN4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Liarozole hydrochloride, the hydrochloride salt preparation of Liarozole, is an imidazole-containing compound that suppresses cytochrome P-450-dependent metabolism of all-trans-retinoic-acid (ATRA). ATRA has been shown to be a metabolite of vitamin A. Studies report that some of the specific enzymes that are inhibited include CYP26s which are responsible for ATRA metabolism. Liarozole has also demonstrated the ability to inhibit aromatase, a key enzyme that is responsible for an important step in the biosynthesis of estrogens. Liarozole hydrochloride is an inhibitor of CYP19 and CYP26A1.


References

1. Van Wauwe, J., et al. 1992. J. Pharmacol. Exp. Ther. 261: 773-779. PMID: 1374473
2. Njar, V.C., et al. 2006. Bioorg. Med. Chem. 14: 4323-4340. PMID: 16530416
3. Goss, P.E., et al. 2007. BMC Cancer. 7: 26. PMID: 17266767
4. Pavez Loriè, E., et al. 2009. Acta Derm. Venereol. 89: 12-20. PMID: 19197536
5. Levy, G. et al. 2014. Fertil. Steril. 102(1): 272-281.e2. PMID: 24825427

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mM), and ethanol (100 mM).
Storage :
Desiccate at room temperature
Boiling Point :
578.2° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
71454
MDL Number :
MFCD00879803
SMILES :
C1=CC(=CC(=C1)Cl)C(C2=CC3=C(C=C2)N=CN3)N4C=CN=C4.Cl

Download SDS (MSDS)

Certificate of Analysis

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